https://scholars.lib.ntu.edu.tw/handle/123456789/635306
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lu, Ching | en_US |
dc.contributor.author | CHAO LUN LAI | en_US |
dc.contributor.author | Yang, Chih-Man | en_US |
dc.contributor.author | Liao, Karen Chia-Wen | en_US |
dc.contributor.author | Kao, Chie-Shung | en_US |
dc.contributor.author | Chang, Tien-Chu | en_US |
dc.contributor.author | Perng, Ming-Der | en_US |
dc.date.accessioned | 2023-09-08T09:02:52Z | - |
dc.date.available | 2023-09-08T09:02:52Z | - |
dc.date.issued | 2022-11-29 | - |
dc.identifier.issn | 1010660X | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85144550572&doi=10.3390%2fmedicina58121748&origin=inward&txGid=aef8be5f5c5788efcb67a6c21732d4e4 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/635306 | - |
dc.description.abstract | Background and Objectives: The aim of this study was to investigate the relationships between obesity-related factors including body mass index (BMI), diabetes or prediabetes, hyperlipidemia, fasting plasma glucose, fasting plasma insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), highly sensitive C-reactive protein (hs-CRP) and Graves' orbitopathy (GO). Materials and Methods: Eighty-four patients with Graves' disease (GD) (42 without GO and 42 with GO) were enrolled in this cross-sectional cohort study. Gender, age, GD treatment history, height, body weight, waist circumference, smoking status, co-morbidities, levels of free thyroxin, thyroid-stimulating hormone, thyroid-stimulating hormone receptor (TSHR) antibodies, fasting plasma glucose and insulin, and hs-CRP were recorded. The eye condition was evaluated using the consensus statement of the European Group of Graves' Orbitopathy (EUGOGO) and the NOSPECS classification. Results: In this study, multivariate regression analysis showed that BMI, fasting plasma insulin, and HOMA-IR were associated with the presence of GO after adjusting the age, gender, smoking, TSHR antibodies, and steroid usage (adjusted odd's ratio (aOR) 1.182, 95% confidence interval (95% CI), 1.003-1.393, p = 0.046; aOR 1.165, 95% CI, 1.001-1.355, p = 0.048; and aOR 1.985, 95% CI, 1.046-3.764, p = 0.036, respectively). In addition, BMI, fasting plasma glucose, fasting plasma insulin, HOMA-IR, and hs-CRP levels were positively correlated with the severity of GO. Conclusions: The findings of this study suggest that obesity-related factors, especially fasting plasma insulin and HOMA-IR, are related to GO. Our study highlighted the importance of obesity-related factors in GO. Obesity-related factors may cause the development of GO or occur simultaneously with GO. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Medicina (Kaunas, Lithuania) | en_US |
dc.subject | Graves’ orbitopathy; body mass index; fasting plasma insulin; homeostasis model assessment-estimated insulin resistance | en_US |
dc.title | The Relationship between Obesity-Related Factors and Graves' Orbitopathy: A Pilot Study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/medicina58121748 | - |
dc.identifier.pmid | 36556950 | - |
dc.identifier.scopus | 2-s2.0-85144550572 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85144550572 | - |
dc.relation.pages | 1478 | en_US |
dc.relation.journalvolume | 58 | en_US |
dc.relation.journalissue | 12 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.orcid | 0000-0002-0362-245X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
顯示於: | 醫學系 |
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