https://scholars.lib.ntu.edu.tw/handle/123456789/635338
標題: | Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis | 作者: | Hawkes, Jason E Yan, Bernice Y CHIH-CHIEH CHAN Krueger, James G |
公開日期: | 15-九月-2018 | 卷: | 201 | 期: | 6 | 來源出版物: | Journal of immunology (Baltimore, Md. : 1950) | 摘要: | Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also associated with multiple comorbid conditions, such as joint destruction, cardiovascular disease, stroke, hypertension, metabolic syndrome, and chronic kidney disease. The discovery of IL-17-producing T cells in a mouse model of autoimmunity transformed our understanding of inflammation driven by T lymphocytes and associations with human inflammatory diseases, such as psoriasis. Under the regulation of IL-23, T cells that produce high levels of IL-17 create a self-amplifying, feed-forward inflammatory response in keratinocytes that drives the development of thickened skin lesions infiltrated with a mixture of inflammatory cell populations. Recently, the Food and Drug Administration approved multiple highly effective psoriasis therapies that disrupt IL-17 (secukinumab, ixekizumab, and brodalumab) and IL-23 (guselkumab and tildrakizumab) signaling in the skin, thus leading to a major paradigm shift in the way that psoriatic disease is managed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635338 | ISSN: | 00221767 | DOI: | 10.4049/jimmunol.1800013 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。