https://scholars.lib.ntu.edu.tw/handle/123456789/635380
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Verstovsek, Srdan | en_US |
dc.contributor.author | Komatsu, Norio | en_US |
dc.contributor.author | Gill, Harinder | en_US |
dc.contributor.author | Jin, Jie | en_US |
dc.contributor.author | Lee, Sung-Eun | en_US |
dc.contributor.author | HSIN-AN HOU | en_US |
dc.contributor.author | Sato, Toshiaki | en_US |
dc.contributor.author | Qin, Albert | en_US |
dc.contributor.author | Urbanski, Raymond | en_US |
dc.contributor.author | Shih, Weichung | en_US |
dc.contributor.author | Zagrijtschuk, Oleh | en_US |
dc.contributor.author | Zimmerman, Craig | en_US |
dc.contributor.author | Mesa, Ruben A | en_US |
dc.date.accessioned | 2023-09-14T07:00:45Z | - |
dc.date.available | 2023-09-14T07:00:45Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 14796694 | - |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/35924546/ | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138514378&doi=10.2217%2ffon-2022-0596&partnerID=40&md5=ca7fa0816ff0b345ec3427f64c82bb8f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/635380 | - |
dc.description.abstract | Patients diagnosed with high-risk essential thrombocythemia (ET) have limited treatment options to reduce the risk of thrombosis and lessen the progression of the disease by targeting the molecular source. Hydroxyurea is the recommended treatment, but many patients experience resistance or intolerance. Anagrelide is an approved second-line option for ET, but concerns of a higher frequency of disease transformation may affect its role as a suitable long-term option. Interferons have been evaluated in myeloproliferative neoplasms for over 30 years, but early formulations had safety and tolerability issues. SURPASS-ET (NCT04285086) is a phase III, open-label, multicenter, global, randomized, active-controlled trial that will evaluate the safety, efficacy, tolerability and pharmacokinetics of ropeginterferon alfa-2b compared with anagrelide as second-line therapy in high-risk ET. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Future oncology (London, England) | en_US |
dc.subject | P1101; SURPASS-ET; anagrelide; essential thrombocythemia; hydroxyurea; interferon; myeloproliferative neoplasm; pegylated interferon; ropeginterferon alfa-2b | en_US |
dc.title | SURPASS-ET: phase III study of ropeginterferon alfa-2b versus anagrelide as second-line therapy in essential thrombocythemia | en_US |
dc.type | journal article | en |
dc.type | review | en_US |
dc.identifier.doi | 10.2217/fon-2022-0596 | - |
dc.identifier.pmid | 35924546 | - |
dc.identifier.scopus | 2-s2.0-85138514378 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85138514378 | - |
dc.relation.pages | 2999 | en_US |
dc.relation.journalvolume | 18 | en_US |
dc.relation.journalissue | 27 | en_US |
dc.relation.pageend | 3009 | en_US |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-2780-4845 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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