https://scholars.lib.ntu.edu.tw/handle/123456789/635462
Title: | Glaucocalyxin A attenuates carbon tetrachloride-induced liver fibrosis and improves the associated gut microbiota imbalance | Authors: | Qu, Ru Zhang, Wang Ma, Zhuang Ma, Qianwen MING-JU CHEN Lan, Tian Zhou, Lin Hu, Xuguang |
Keywords: | carbon tetrachloride | glaucocalyxin A | gut microbiota | inflammation | liver fibrosis | Issue Date: | 1-Jul-2023 | Journal Volume: | 102 | Journal Issue: | 1 | Source: | Chemical Biology and Drug Design | Abstract: | Liver fibrosis refers to the pathophysiological process of dysplasia on the connective tissue of the liver, caused by a variety of pathogenic factors. Glaucocalyxin A (GLA) has anticoagulation, antibacterial, anti-inflammation, antioxidant and antitumour properties. However, whether GLA ameliorates liver fibrosis or not is still unclear. In this study, a liver fibrosis model was established using male C57BL/6 mice. The mice were treated with 5 and 10 mg/kg GLA via intraperitoneal injection, respectively. The ones that were treated with 5 mg/kg OCA were used as the positive control group. The levels of liver function, liver fibrosis biomarkers and liver pathological changes were then evaluated. We also explored the effects of GLA on inflammatory response and liver cell apoptosis. In addition, we investigated the gut microbiota mechanisms of GLA on liver fibrosis. The results from this study that GLA could significantly decrease the level of liver function (AST, ALT, TBA) and liver fibrosis (HA, LN, PC-III, IV-C). On the other hand, a significant decrease in inflammation levels (IL-1β, TNF-α) were also noted. GLA also improves CCl4-induced pathological liver injuries and collagen deposition, in addition to decreasing apoptosis levels. In addition, an increase in the ratio of Bacteroidetes and Firmicutes in liver disease was also observed. GLA also improves the gut microbiota. In conclusion, GLA attenuates CCl4-induced liver fibrosis and improves the associated gut microbiota imbalance. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153309514&doi=10.1111%2fcbdd.14241&partnerID=40&md5=2793dd06ec54b86cc6a4c0f1979ec85e https://scholars.lib.ntu.edu.tw/handle/123456789/635462 |
ISSN: | 17470277 | DOI: | 10.1111/cbdd.14241 |
Appears in Collections: | 動物科學技術學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.