https://scholars.lib.ntu.edu.tw/handle/123456789/635838
標題: | Investigating the risk of metabolic and cardiovascular comorbidities among patients with parathyroid cancer: a nationwide representative cohort study in Taiwan | 作者: | Tsai, Ming Chieh Hsu, Min Shu Hsu, Hsin Yin Yeh, Tzu Lin CHUN-JU CHIANG WEN-CHUNG LEE Jhuang, Jing Rong Cheng, Shih Ping Tseng, Po Jung KUO-LIONG CHIEN |
關鍵字: | Cardiovascular disease | Diabetes mellitus | Parathyroid cancer | 公開日期: | 1-十二月-2023 | 出版社: | BMC Springer Nature | 卷: | 21 | 期: | 1 | 起(迄)頁: | 249 | 來源出版物: | BMC Medicine | 摘要: | Background: This study aimed to determine whether primary parathyroid cancer patients were associated with increased metabolic and cardiovascular comorbidities in comparison to the general population. Methods: We used the National Taiwan Cancer Registry Database to construct a cohort of patients with parathyroid cancer from January 1, 2004, to December 31, 2019. We compared the incidence of hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, coronary heart disease, and heart failure with the general population matched based on a propensity score in a one-to-five fashion. Results: A total of 72 parathyroid cancer patients and 360 matched general population (mean age: 55 years; 59% women) were included, with different exclusive numbers for each metabolic and cardiovascular comorbidity cohort. The number of cases based on a total of 2347.7 person-years of observation included 53 deaths, 29 hypertension, 9 diabetes, 13 hyperlipidemia, 10 atrial fibrillation, 18 coronary artery disease, and 13 heart failure. According to multivariate analysis, parathyroid cancer remained significantly associated with diabetes [hazard ratio (HR): 9.28; 95% confidence interval (CI): 1.72–50.07], hyperlipidemia (HR: 5.86; 95% CI: 1.61–21.31), and heart failure (HR: 4.46; 95% CI: 1.18–16.84). Sub-distribution of competing mortality events and subgroup analysis showed robust evidence of metabolic and cardiovascular comorbidities. This national cohort study demonstrated that adult parathyroid cancer patients had a significantly higher incidence of diabetes mellitus, hyperlipidemia, and heart failure than the general population. Conclusions: An increased risk of metabolic and cardiac comorbidities among parathyroid cancer patients required great caution. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635838 | ISSN: | 1741-7015 | DOI: | 10.1186/s12916-023-02946-z |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。