https://scholars.lib.ntu.edu.tw/handle/123456789/636227
標題: | The Association between 4-Tertiary-Octylphenol, Apoptotic Microparticles, and Carotid Intima-Media Thickness in a Young Taiwanese Population | 作者: | Lin, Chien-Yu CHING-WAY CHEN Wang, Chikang Sung, Fung-Chang TA-CHEN SU |
關鍵字: | 4-tertiary-octylphenol (4-tOP); CD31+/CD42a+; CD31+/CD42a−; apoptotic microparticles; common carotid artery intima-media thickness (CIMT) | 公開日期: | 6-九月-2023 | 卷: | 11 | 期: | 9 | 起(迄)頁: | 757 | 來源出版物: | Toxics | 摘要: | As one of the most common alkylphenols, 4-tertiary-octylphenol (4-tOP) is commonly used in many consumer products. Our previous epidemiological study revealed a negative correlation between serum 4-tOP levels and carotid intima-media thickness (CIMT), which serves as a biomarker of arteriosclerosis. We aimed to explore the role of apoptotic microparticles, markers of vascular endothelial cell function, in the 4-tOP and CIMT connection. To investigate this, we enrolled 886 Taiwanese adolescents and young adults (aged 12-30 years) and examined the relationships among serum 4-tOP levels, apoptotic microparticles (CD31+/CD42a-, CD31+/CD42a+), and CIMT. Our results showed negative associations among serum 4-tOP levels, both apoptotic microparticles, and CIMT in multiple linear regression analysis. The odds ratios for CIMT (≥75th percentile) and the natural logarithm of 4-tOP were highest when both CD31+/CD42a- and CD31+/CD42a+ were greater than the 50th percentile. Conversely, the odds ratios were lowest when both CD31+/CD42a- and CD31+/CD42a+ were less than the 50th percentile. In the structural equation model, we demonstrated that serum 4-tOP levels were negatively correlated with CIMT and indirectly and negatively correlated with CIMT through both apoptotic microparticles. In conclusion, our study reported the inverse association between 4-tOP apoptotic microparticles and CIMT in a young Taiwanese population. Further experimental studies are needed to clarify these associations. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85172270495&origin=resultslist&sort=plf-f https://scholars.lib.ntu.edu.tw/handle/123456789/636227 |
ISSN: | 2305-6304 | DOI: | 10.3390/toxics11090757 |
顯示於: | 醫學系 |
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