https://scholars.lib.ntu.edu.tw/handle/123456789/636419
標題: | The Impact of Nontuberculous Mycobacteria Species on Mortality in Patients With Nontuberculous Mycobacterial Lung Disease | 作者: | Wang, Ping-Huai Pan, Sheng-Wei Wang, Su-Mei CHIN-CHUNG SHU Chang, Chin-Hao |
關鍵字: | Mycobacterium kansasii; chronic airway disease; lung disease; mortality; non-cancer; nontuberculous mycobacteria; species | 公開日期: | 2022 | 卷: | 13 | 起(迄)頁: | 909274 | 來源出版物: | Frontiers in microbiology | 摘要: | Patients with nontuberculous mycobacterial lung disease (NTM-LD) have increased mortality. The impact of NTM species on the risk of mortality remains unclear, especially that of death by non-cancer causes. We conducted a retrospective cohort study from 2006 to 2018 in a tertiary-care hospital in Taiwan. We enrolled patients who fulfilled the microbiological diagnostic criteria of NTM-LD. The mortality causes within 8 years after diagnosis were identified, and the Cox proportional hazard regression was performed for risk factors of mortality. A total of 1,652 subjects with NTM-LD were included. Among them, 723 (43.8%) were infected by Mycobacterium avium complex (MAC), 408 (24.7%) by M. abscessus complex (MABC), 120 (7.3%) by Mycobacterium kansasii (MK), 304 (18.4%) by other rapid-growing mycobacteria (RGM), and 97 (5.9%) by other slow-growing mycobacteria (SGM) groups. The 8-year all-cause mortality was 45.2% for all and the highest in the MK-LD group (59.2%), followed by the MABC-LD and MAC-LD groups. The adjusted hazard ratios were 2.20 (95% confidence interval: 1.40-3.46) in the MK-LD, 1.85 (1.54-2.22) in the MABC-LD, and 1.65 (1.12-2.41) in the MAC-LD groups for all-cause mortality, compared with the SGM group. Kaplan-Meier survival curves showed that all-cause mortality, non-cancer mortality, and mortality due to chronic airway diseases were significantly correlated with NTM species (log-rank p = 0.0031, < 0.001, and 0.001, respectively). High 8-year mortality rates were found in patients with NTM-LDs according to different NTM species. Notably, the difference was significant in non-cancer mortality causes, especially in chronic airway diseases. |
URI: | https://pubmed.ncbi.nlm.nih.gov/35875534/ https://scholars.lib.ntu.edu.tw/handle/123456789/636419 |
ISSN: | 1664-302X | DOI: | 10.3389/fmicb.2022.909274 |
顯示於: | 醫學系 |
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