https://scholars.lib.ntu.edu.tw/handle/123456789/636703
標題: | DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRASG12C-mutant cancer | 作者: | Chiou, Li-Wen Chan, Chien-Hui Jhuang, Yu-Ling CHING-YAO YANG YUNG-MING JENG |
關鍵字: | Drug addiction; KRAS; Mitotic catastrophe; Replication stress; Sotorasib | 公開日期: | 29-六月-2023 | 卷: | 30 | 期: | 1 | 來源出版物: | Journal of biomedical science | 摘要: | Sotorasib is the first KRASG12C inhibitor approved by the US Food and Drug Administration for treating KRASG12C-mutant non-small-cell lung cancer (NSCLC). Clinical trials on the therapeutic use of sotorasib for cancer have reported promising results. However, KRASG12C-mutant cancers can acquire resistance to sotorasib after treatment. We incidentally discovered that sotorasib-resistant (SR) cancer cells are addicted to this inhibitor. In this study, we investigated the mechanisms underlying sotorasib addiction. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/636703 | ISSN: | 10217770 | DOI: | 10.1186/s12929-023-00940-4 |
顯示於: | 病理學科所 |
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