https://scholars.lib.ntu.edu.tw/handle/123456789/636831
標題: | Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy | 作者: | Chan, Ming-Hsien Chen, Bo-Gu Li, Chien-Hsiu Huang, Wen-Tse Su, Ting-Yi Yin, Lichang Hsiao, Michael RU-SHI LIU |
公開日期: | 5-十月-2023 | 卷: | 15 | 期: | 38 | 起(迄)頁: | 15558 | 來源出版物: | Nanoscale | 摘要: | Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles. Carbon quantum dots (CDs) have excellent biocompatibility and fluorescence properties as a substrate carrying a single atom. It is difficult to break through pure-phase single-atom materials with quantum dots as carriers. In addition, there is currently no related research in the single-atom field in the context of oral cancer, especially head and neck squamous cell carcinoma. This research developed a lipid surface-coated nanozyme combined with CDs, single-atomic gold, and modified lipid ligands (DSPE-PEG) with transferrin (Tf) to treat oral squamous cell carcinoma. The study results have demonstrated that surface-modified single-atom carbon quantum dots (m-SACDs) exhibit excellent therapeutic effects and enable in situ image tracking for diagnosing and treating head and neck squamous carcinoma (HNSCC). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/636831 | ISSN: | 20403364 | DOI: | 10.1039/d3nr02088f |
顯示於: | 化學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。