https://scholars.lib.ntu.edu.tw/handle/123456789/637247
標題: | A Pilot Study of Nephrogenic Probiotics to Further Improve an Already Stabilized Graft Function After Kidney Transplantation | 作者: | Chan, Wai Nga Ho, Dong Ru Huang, Yun Ching Lin, Jian Hui Liu, Yu Liang MING-JU CHEN Chen, Chih Shou |
公開日期: | 1-一月-2023 | 卷: | 55 | 期: | 9 | 起(迄)頁: | 2090-2094 | 來源出版物: | Transplantation Proceedings | 摘要: | Background: The majority of kidney recipients are a subset of chronic kidney disease. Our previous study demonstrated that the combination of Lactobacillus plantarum and Lactobacillus paracasei (Lm) had the highest clearance ability of uremic toxins and improved kidney function in a mouse model. This study aimed to evaluate Lm in improving graft function, effects on immunosuppressants, and safety in transplant recipients. Methods: We retrospectively reviewed 24 patients. Twelve of them take Lm regularly; we compared the creatinine measurements and estimated glomerular filtration rate 3 months before and after Lm using a 2-tailed Wilcoxon matched-pairs signed-rank test while also evaluating the drug level of immunosuppressants and infection events. Other 12 patients who do not have Lm for evaluation of laboratory calibration and compared the proportion of improving creatinine using Fisher's exact test. Results: The creatinine decreased by 0.06 mg/dL (P = .02), and the estimated glomerular filtration rate increased by 3.1 mL/min/1.73 m2 (P = .03) after Lm supplementation. This pilot study revealed the association of higher incidence (odds ratio 13.3, 95% CI 1.64-77.2, P = .01) of decreasing creatinine in transplant recipients using Lm. Furthermore, results showed a trend of higher trough levels of tacrolimus and sirolimus, which might provide a potential strategy for reducing the dosages of immunosuppressants. Conclusion: Our findings revealed an association between a higher incidence of decreasing creatinine in kidney transplant recipients using Lm, which may also provide a potential strategy for reducing the acquired dosages of immunosuppressants. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85173422812&doi=10.1016%2fj.transproceed.2023.08.011&partnerID=40&md5=dd40e0f55ba3b2a828eab13c3ea23168 https://scholars.lib.ntu.edu.tw/handle/123456789/637247 |
ISSN: | 00411345 | DOI: | 10.1016/j.transproceed.2023.08.011 |
顯示於: | 動物科學技術學系 |
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