https://scholars.lib.ntu.edu.tw/handle/123456789/637399
標題: | Nanodiamonds-in-oil emulsions elicit potent immune responses for effective vaccination and therapeutics | 作者: | Lin, Hsin-Hung Wang, Chih-Yen Hsieh, Feng-Jen Liao, Fang-Zhen Su, Yu-Kai Pham, Minh Dinh CHIH-YUAN LEE Chang, Huan-Cheng HSAO-HSUN HSU |
關鍵字: | adjuvants; antitumor agents; fluorescent nanodiamonds; mice; ovalbumin; vaccine | 公開日期: | 七月-2023 | 卷: | 18 | 期: | 16 | 來源出版物: | Nanomedicine (London, England) | 摘要: | Background: The use of nanodiamonds (NDs) and fluorescent nanodiamonds (FNDs) as nonallergenic biocompatible additives in incomplete Freund's adjuvant (IFA) to elicit immune responses in vivo was investigated. Methods: C57BL/6 mice were immunized with chicken egg ovalbumin (OVA) in IFA and also OVA-conjugated NDs (or OVA-conjugated FNDs) in IFA to produce antibodies. OVA-expressing E.G7 lymphoma cells and OVA-negative EL4 cells were inoculated in mice to induce tumor formation. Results: The new formulation significantly enhanced immune responses and thus disease resistance. It exhibited specific therapeutic activities, effectively inhibiting the growth of E.G7 tumor cells in mice over 35 days. Conclusion: The high biocompatibility and multiple functionalities of NDs/FNDs render them applicable as active and trackable vaccine adjuvants and antitumor agents. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637399 | ISSN: | 17435889 | DOI: | 10.2217/nnm-2023-0179 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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