https://scholars.lib.ntu.edu.tw/handle/123456789/637422
標題: | The CAM Model—Q&A with Experts | 作者: | Fischer, Dagmar Fluegen, Georg Garcia, Paul Ghaffari-Tabrizi-Wizsy, Nassim Gribaldo, Laura RUBY YUN-JU HUANG Rasche, Volker Ribatti, Domenico Rousset, Xavier Pinto, Marta Texeira Viallet, Jean Wang, Yan Schneider-Stock, Regine |
關鍵字: | angiogenesis model | drug discovery | immune-oncology | metastasis model | personalized therapy | standard operation procedures | tumor growth | 公開日期: | 1-一月-2023 | 卷: | 15 | 期: | 1 | 來源出版物: | Cancers | 摘要: | The chick chorioallantoic membrane (CAM), as an extraembryonic tissue layer generated by the fusion of the chorion with the vascularized allantoic membrane, is easily accessible for manipulation. Indeed, grafting tumor cells on the CAM lets xenografts/ovografts develop in a few days for further investigations. Thus, the CAM model represents an alternative test system that is a simple, fast, and low-cost tool to study tumor growth, drug response, or angiogenesis in vivo. Recently, a new era for the CAM model in immune-oncology-based drug discovery has been opened up. Although there are many advantages offering extraordinary and unique applications in cancer research, it has also disadvantages and limitations. This review will discuss the pros and cons with experts in the field. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637422 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers15010191 |
顯示於: | 醫學系 |
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