https://scholars.lib.ntu.edu.tw/handle/123456789/637603
標題: | Eif4e3 is an immune infiltration correlated prognosticator in colon cancer | 作者: | Guo, Y. Q. Jiang, Y. Z. CHUNG-HSIN CHEN Wu, L. J. Chen, K. S. Xia, J. J. Liu, Zhen Yin |
關鍵字: | Colon cancer | EIF4E3 | Immune infiltration | Prognosticator | Th17 cells | 公開日期: | 1-九月-2021 | 卷: | 35 | 期: | 5 | 來源出版物: | Journal of Biological Regulators and Homeostatic Agents | 摘要: | Colon cancer is a highly malignant gastrointestinal cancer, and genes in the tumor infiltrating cells and microenvironment are emerging as pivotal players in its development and prognosis. In this study, TIMER and StarBase tools were used to find whether EIF4E3 gene was downregulated in colon tissues, and whether lower expression of EIF4E3 was associated with poor prognosis in colon cancer patients, as well as to ascertain that EIF4E3 could regulate immune-related pathways by gene set enrichment analysis (GSEA). Using TIMER (Tumor Immune Estimation Resource) database and ImmuneCellAI tools, it was found that EIF4E3 expression was correlated with tumor immune infiltrates in colon cancer. The results identified EIF4E3 as an immune infiltrate-correlated prognosticator in colon cancer. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637603 | ISSN: | 0393974X | DOI: | 10.23812/21-176-A |
顯示於: | 醫學系 |
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