https://scholars.lib.ntu.edu.tw/handle/123456789/637661
標題: | Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination | 作者: | Lin, Pin-Hung Hsiao, Po-Ju Pan, Ching-Fu Liu, Ming-Tsan JANN-TAY WANG Ching, Chi Wu, Fang-Yi Lin, Yi-Hsuan Yang, Yu-Chan Hsu, Le-Yin HUNG-CHIH YANG UN-IN WU |
關鍵字: | Influenza; Regulatory T cells; Repeated vaccination; Seroconversion; Seroprotection | 公開日期: | 15-九月-2023 | 來源出版物: | European journal of immunology | 摘要: | Repeated annual influenza vaccinations have been associated with reduced vaccine-induced antibody responses. This prospective study aimed to explore the role of vaccine antigen-specific regulatory T (Treg) cells in antibody response to repeated annual influenza vaccination. We analyzed pre- and postvaccination hemagglutination inhibition (HI) titers, seroconversion rates, seroprotection rates, vaccine antigen hemagglutinin (HA)-specific Treg cells, and conventional T (Tconv) cells. We compared these parameters between vaccinees with or without vaccine-induced seroconversion. Our multivariate logistic regression revealed that prior vaccination was significantly associated with a decreased likelihood of achieving seroconversion for both H1N1(adjusted OR, 0.03; 95% CI, 0.01-0.13) and H3N2 (adjusted OR, 0.09; 95% CI, 0.03-0.30). Furthermore, individuals who received repeated vaccinations had significantly higher levels of pre-existing HA-specific Treg cells than those who did not. We also found that vaccine-induced fold-increases in HI titers and seroconversion were negatively correlated with pre-existing HA-specific Treg cells and positively correlated with the ratio of Tconv to Treg cells. Overall, our findings suggest that repeated annual influenza vaccination is associated with a lower vaccine-induced antibody response and a higher frequency of vaccine-specific Treg cells. However, a lower frequency of pre-existing Treg cells correlates with a higher postvaccination antibody response. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637661 | ISSN: | 00142980 | DOI: | 10.1002/eji.202350525 |
顯示於: | 醫學系 |
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