https://scholars.lib.ntu.edu.tw/handle/123456789/637697
Title: | Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement | Authors: | Teng, Ling-Ling Lu, Guan-Ling LIH-CHU CHIOU Lin, Wei-Sheng Cheng, Ya-Yun Hsueh, Tai-En Huang, Yi-Ching Hwang, Nai-Hsuan Yeh, Jin-Wei Liao, Ruey-Ming SHOU-ZEN FAN Yen, Jui-Hung Fu, Tsai-Feng Tsai, Ting-Fen MING-SHIANG WU PEI-YU WANG |
Issue Date: | Mar-2019 | Journal Volume: | 17 | Journal Issue: | 3 | Source: | PLoS biology | Abstract: | Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637697 | ISSN: | 15449173 | DOI: | 10.1371/journal.pbio.2007097 |
Appears in Collections: | 醫學系 |
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