https://scholars.lib.ntu.edu.tw/handle/123456789/638122
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Yi Hsieng Samuel | en_US |
dc.contributor.author | Lin, Yi Ling | en_US |
dc.contributor.author | Kao, Yi Feng | en_US |
dc.contributor.author | Chen, Jr Wei | en_US |
dc.contributor.author | Chen, Yi Chou | en_US |
dc.contributor.author | YI-CHEN CHEN | en_US |
dc.date.accessioned | 2023-12-25T05:35:32Z | - |
dc.date.available | 2023-12-25T05:35:32Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 15204081 | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85178418508&origin=resultslist | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/638122 | - |
dc.description.abstract | Tons of broiler livers are produced yearly in Taiwan but always considered waste. Our team has successfully patented and characterized a chicken-liver hydrolysate (CLH) with several biofunctions. Chronic alcohol consumption causes hepatosteatosis or even hepatitis, cirrhosis, and cancers. This study was to investigate the hepatoprotection of CLH-based supplement (GBHP01™) against chronic alcohol consumption. Results showed that GBHP01™ could reduce (p <.05) enlarged liver size, lipid accumulation/steatosis scores, and higher serum AST, ALT, γ-GT, triglyceride, and cholesterol levels induced by an alcoholic liquid diet. GBHP01™ reduced liver inflammation and apoptosis in alcoholic liquid-diet-fed mice via decreasing TBARS, interleukin-6, interleukin-1β, and tumor necrosis factor-α levels, increasing reduced GSH/TEAC levels and activities of SOD, CAT and GPx, as well as downregulating CYP2E1, BAX/BCL2, Cleaved CASPASE-9/Total CASPASE-9 and Active CASPASE-3/Pro-CASPASE-3 (p <.05). Furthermore, GBHP01™ elevated hepatic alcohol metabolism (ADH and ALDH activities) (p <.05). In conclusion, this study prove the hepatoprotection of GBHP01™ against alcohol consumption. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Environmental Toxicology | en_US |
dc.subject | alcohol metabolism | anti-inflammatory response | antiapoptosis | antioxidant capacity | chicken-liver hydrolysate-based supplement | en_US |
dc.title | A functional chicken-liver hydrolysate-based supplement ameliorates alcohol liver disease via regulation of antioxidation, anti-inflammation, and antiapoptosis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/tox.24072 | - |
dc.identifier.pmid | 38054388 | - |
dc.identifier.scopus | 2-s2.0-85178418508 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85178418508 | - |
dc.relation.pages | 1759 - 1768 | - |
dc.relation.journalvolume | 39 | - |
dc.relation.journalissue | 3 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.orcid | 0000-0002-4616-2115 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | International College | - |
顯示於: | 動物科學技術學系 |
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