https://scholars.lib.ntu.edu.tw/handle/123456789/638569
標題: | Imaging of skin dermal thermal damage by multiphoton autofluroescence and second harmonic generation (SHG) microscopy | 作者: | TSUNG-LIN YANG Chiang, Cheng Tien Kao, Hsien Ching Lo, Wen SUNG-JAN LIN SHIOU-HWA JEE YANG-FANG CHEN CHEN-YUAN DONG |
關鍵字: | Autofluorescence | Collagen | Elastin | Multiphoton imaging | Second harmonic generation | Thermal damage | 公開日期: | 8-五月-2006 | 卷: | 6078 | 來源出版物: | Progress in Biomedical Optics and Imaging - Proceedings of SPIE | 摘要: | Multiphoton autofluorescence and second harmonic generation (SHG) microscopy are useful in respectively identifying elastin and collagen fibers within the skin dermis. In this study, we attempt to characterize the degree of skin thermal damage by using multiphoton microscopy to characterize the thermal changes to collagen and elastin fibers. We found that autofluorescence and SHG imaging behave differently in skin dermis treated with different temperatures and that an index reflecting the relative changes in autofluorescence and SHG intensity is useful to identify the degree of dermal thermal damage to the skin. With additional development, our approach can be used to identify the extent of thermal damage in patients. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/638569 | ISBN: | 0819461202 | ISSN: | 16057422 | DOI: | 10.1117/12.647406 |
顯示於: | 醫學工程學研究所 |
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