https://scholars.lib.ntu.edu.tw/handle/123456789/639178
標題: | Association of HLA-te22 antigen with anti-nuclear antibodies in Chinese patients with erosive oral lichen planus | 作者: | ANDY SUN Wu, Y C Wang, J T Liu, B Y CHUN-PIN CHIANG |
公開日期: | 四月-2000 | 卷: | 24 | 期: | 2 | 來源出版物: | Proceedings of the National Science Council, Republic of China. Part B, Life sciences | 摘要: | The purpose of this study was to determine the frequencies of the presence of serum anti-nuclear antibodies (ANA) and smooth muscle antibodies (SMA) in 76 patients with oral lichen planus (OLP), in 77 patients with other oral mucosal diseases, and in 41 healthy control subjects. HLA phenotypes in some of the patients with OLP and recurrent aphthous ulcers (RAU) were determined to show whether there was an association of HLA antigens with the presence of autoantibodies. Indirect immunofluorescence techniques with mouse liver or stomach as the substrate were used to detect the serum ANA or SMA, respectively. The B lymphocytes isolated from peripheral blood were used for HLA typing by means of a standard microcytotoxicity assay. We found that the positive rate of serum ANA in patients with OLP (29%, p < 0.01), especially in patients with erosive OLP (34%, p < 0.001), was significantly higher than that in the normal control subjects (5%). The frequency of serum SMA in patients with OLP (20%, p < 0.01), in patients with RAU (17%, p < 0.01), or in patients with oral squamous cell carcinomas (41%, p < 0.001) was also significantly higher than that in normal control individuals (0%). In the erosive OLP group, the HLA-Te22 antigen occurred more frequently in patients with positive ANA (75%, p < 0.05) than in those with negative ANA (25%). We conclude that there is an association of HLA-Te22 antigen with ANA in Chinese patients with erosive OLP. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639178 | ISSN: | 0255-6596 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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