https://scholars.lib.ntu.edu.tw/handle/123456789/639998
標題: | Impact of selection bias on polygenic risk score estimates in healthcare settings | 作者: | Lee, Younga Heather Thaweethai, Tanayott Sheu, Yi-Han YEN-CHEN ANNE FENG Karlson, Elizabeth W Ge, Tian Kraft, Peter Smoller, Jordan W |
關鍵字: | biobank; causal inference; inverse probability weighting; polygenic risk score; selection bias | 公開日期: | 十一月-2023 | 卷: | 53 | 期: | 15 | 起(迄)頁: | 7435 | 來源出版物: | Psychological Medicine | 摘要: | Hospital-based biobanks are being increasingly considered as a resource for translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks originate from patient populations, there is a possibility of bias in polygenic risk estimation due to overrepresentation of patients with higher frequency of healthcare interactions. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/639998 | ISSN: | 00332917 | DOI: | 10.1017/S0033291723001186 |
顯示於: | 流行病學與預防醫學研究所 |
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