https://scholars.lib.ntu.edu.tw/handle/123456789/640028
標題: | Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma | 作者: | Wechsler, Michael E Scelo, Ghislaine Larenas-Linnemann, Désirée E S Torres-Duque, Carlos A Maspero, Jorge Tran, Trung N Murray, Ruth B Martin, Neil Menzies-Gow, Andrew N Hew, Mark Peters, Matthew J Gibson, Peter G Christoff, George C Popov, Todor A Côté, Andréanne Bergeron, Celine Dorscheid, Delbert FitzGerald, J Mark Chapman, Kenneth R Boulet, Louis Philippe Bhutani, Mohit Sadatsafavi, Mohsen Jiménez-Maldonado, Libardo Duran-Silva, Mauricio Rodriguez, Bellanid Celis-Preciado, Carlos Andres Cano-Rosales, Diana Jimena Solarte, Ivan Fernandez-Sanchez, Maria Jose Parada-Tovar, Patricia von Bülow, Anna Bjerrum, Anne Sofie Ulrik, Charlotte S Assing, Karin Dahl Rasmussen, Linda Makowska Hansen, Susanne Altraja, Alan Bourdin, Arnaud Taille, Camille Charriot, Jeremy Roche, Nicolas Papaioannou, Andriana I Kostikas, Konstantinos Papadopoulos, Nikolaos G Salvi, Sundeep Long, Deirdre Mitchell, Patrick D Costello, Richard Sirena, Concetta Cardini, Cristina Heffler, Enrico Puggioni, Francesca Canonica, Giorgio Walter Guida, Giuseppe Iwanaga, Takashi Al-Ahmad, Mona García, Ulises Kuna, Piotr Fonseca, João A Al-Lehebi, Riyad Koh, Mariko S Rhee, Chin Kook Cosio, Borja G Perez de Llano, Luis Perng, Diahn-Warng Steve Huang, Erick Wan-Chun HAO-CHIEN WANG Tsai, Ming-Ju Mahboub, Bassam Salameh, Laila Ibraheem Jaber Jackson, David J Busby, John Heaney, Liam G Pfeffer, Paul E Goddard, Amanda Grippen Wang, Eileen Hoyte, Flavia C L Chapman, Nicholas M Katial, Rohit Carter, Victoria Bulathsinhala, Lakmini Eleangovan, Neva Ariti, Con Lyu, Juntao Porsbjerg, Celeste Price, David B |
關鍵字: | allergic rhinitis; chronic rhinosinusitis; nasal polyposis | 公開日期: | 1-二月-2024 | 卷: | 209 | 期: | 3 | 來源出版物: | American journal of respiratory and critical care medicine | 摘要: | Rationale: Previous studies investigating the impact of comorbidities on the effectiveness of biologic agents have been relatively small and of short duration and have not compared classes of biologic agents. Objectives: To determine the association between type 2-related comorbidities and biologic agent effectiveness in adults with severe asthma (SA). Methods: This cohort study used International Severe Asthma Registry data from 21 countries (2017-2022) to quantify changes in four outcomes before and after biologic therapy-annual asthma exacerbation rate, FEV1% predicted, asthma control, and long-term oral corticosteroid daily dose-in patients with or without allergic rhinitis, chronic rhinosinusitis (CRS) with or without nasal polyps (NPs), NPs, or eczema/atopic dermatitis. Measurements and Main Results: Of 1,765 patients, 1,257, 421, and 87 initiated anti-IL-5/5 receptor, anti-IgE, and anti-IL-4/13 therapies, respectively. In general, pre- versus post-biologic therapy improvements were noted in all four asthma outcomes assessed, irrespective of comorbidity status. However, patients with comorbid CRS with or without NPs experienced 23% fewer exacerbations per year (95% CI, 10-35%; P < 0.001) and had 59% higher odds of better post-biologic therapy asthma control (95% CI, 26-102%; P < 0.001) than those without CRS with or without NPs. Similar estimates were noted for those with comorbid NPs: 22% fewer exacerbations and 56% higher odds of better post-biologic therapy control. Patients with SA and CRS with or without NPs had an additional FEV1% predicted improvement of 3.2% (95% CI, 1.0-5.3; P = 0.004), a trend that was also noted in those with comorbid NPs. The presence of allergic rhinitis or atopic dermatitis was not associated with post-biologic therapy effect for any outcome assessed. Conclusions: These findings highlight the importance of systematic comorbidity evaluation. The presence of CRS with or without NPs or NPs alone may be considered a predictor of the effectiveness of biologic agents in patients with SA. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640028 | ISSN: | 1073-449X 1535-4970 |
DOI: | 10.1164/rccm.202305-0808OC |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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