https://scholars.lib.ntu.edu.tw/handle/123456789/640249
標題: | Air pollution impede ALT normalization in chronic hepatitis B patients treated with nucleotide/nucleoside analogues | 作者: | Jang, Tyng-Yuan Ho, Chi-Chang Wu, Chih-Da Dai, Chia-Yen PAU-CHUNG CHEN |
關鍵字: | air pollution | ALT normalization | HBeAg-negative | HBV | NAs | ozone | 公開日期: | 27-十月-2023 | 出版社: | Lippincott Williams and Wilkins | 卷: | 102 | 期: | 43 | 起(迄)頁: | E34276 | 來源出版物: | Medicine | 摘要: | Biochemical response is an important prognostic indicator in chronic hepatitis B (CHB) patients receiving nucleotide/nucleoside analogues (NAs). However, the effects of air pollution in alanine aminotransferase (ALT) normalization remain elusive. This longitudinal study recruited 80 hepatitis B e antigen-negative CHB patients who received NAs. ALT levels were measured during the first year of anti-hepatitis B virus therapy. Normal ALT levels were defined as <19 U/L for females and <30 U/L for males, and the risk factors associated with ALT abnormalities were analyzed. The daily estimations of air pollutants (particulate matter ≤2.5 µm in diameter (PM2.5), nitrogen dioxide, ozone (O3), and benzene) were aggregated into the mean estimation for the previous month based on the date of recruitment (baseline) and 1 year later. Sixteen patients (20.0%) had a baseline ALT > 40 U/L; overall, 41 (51.6%) had an abnormal ALT (≥19 U/L for females and ≥ 30 U/L for males). After 1 year of NA therapy, 75 patients (93.8%) had undetectable hepatitis B virus DNA levels. Mean post-treatment ALT levels were significantly lower than mean pretreatment levels (21.3 vs 30.0 U/L, respectively; P < .001). The proportion of patients with a normal ALT was also significantly higher after versus before treatment (71.2% vs 51.2%, respectively; P = .001). The strongest factors associated with ALT abnormality after 1 year of NA treatment were body mass index (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.05-1.54; P = .01) and ozone level (OR, 1.11; 95% CI, 1.02-1.22; P = .02). Among hepatitis B e antigen-negative CHB patients with relatively low viral loads, 1 year of NA treatment improved ALT levels after the adjustment for confounding factors and increased the proportion of patients with normal ALT levels. Air pollution affects the efficacy of ALT normalization. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640249 | ISSN: | 00257974 | DOI: | 10.1097/MD.0000000000034276 |
顯示於: | 環境與職業健康科學研究所 |
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