https://scholars.lib.ntu.edu.tw/handle/123456789/640748
標題: | Impact of Postarrest Vasoactive-Inotropic Score on Acute Kidney Injury in Cardiac Arrest Survivors: A Retrospective Cohort Study | 作者: | Tien, Yu Tzu WEN-JONE CHEN CHIEN-HUA HUANG WEI-TING CHEN Ong, Hooi Nee TAO-MIN HUANG WEI-TIEN CHANG MIN-SHAN TSAI |
關鍵字: | acute kidney injury | AKI staging | baseline kidney function | cardiac arrest | vasoactive inotropic score | 公開日期: | 1-一月-2024 | 卷: | 25 | 期: | 1 | 來源出版物: | Reviews in Cardiovascular Medicine | 摘要: | Background: Postarrest acute kidney injury (AKI) is a major health burden because it is associated with prolonged hospitalization, increased dialysis requirement, high mortality, and unfavorable neurological outcomes. Managing hemodynamic instability during the early postarrest period is critical; however, the role of quantified vasopressor dependence in AKI development in relation to illness severity remains unclear. Methods: A retrospective, observational cohort study that enrolled 411 non-traumatic adult cardiac arrest survivors without pre-arrest end-stage kidney disease between January 2017 and December 2019, grouped according to their baseline kidney function. The criteria for kidney injury were based on the Kidney Disease: Improving Global Outcomes definition and AKI staging system. The degree of vasopressor dependence within the first 24 h following return of spontaneous circulation (ROSC) was presented using the maximum vasoactive-inotropic score (VISmax). Results: Of the 411 patients, 181 (44%) had early AKI after ROSC. Patients with AKI showed an increased risk of in-hospital mortality (adjusted OR [aOR] 5.40, 95% CI 3.36-8.69, p < 0.001) and unfavorable neurological outcome (aOR 5.70, 95% CI 3.45-9.43, p < 0.001) compared to patients without AKI. The risk of adverse outcomes increased with illness severity. Patients with vasopressor support had an increased risk of early AKI. A low VISmax was associated with AKI stage 1-2 (aOR 2.51, 95% CI 1.20-5.24), whereas a high VISmax was associated with an increased risk for AKI stage 3 (aOR 2.46, 95% CI 1.28-4.75). Conclusions: Early AKI is associated with an increased risk of in-hospital mortality and unfavorable neurologic recovery in cardiac arrest survivors. Postarrest VISmax is an independent predictor of the development and severity of AKI following ROSC, regardless of baseline kidney function. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/640748 | ISSN: | 15306550 | DOI: | 10.31083/j.rcm2501004 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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