https://scholars.lib.ntu.edu.tw/handle/123456789/641301
標題: | A branched 2-O sulfated 1,3-/1,4-galactoglucan from Antrodia cinnamomea exhibits moderate antiproliferative and anti-inflammatory activities | 作者: | Lu, Mei-Kuang Chao, Chi-Hsein Chang, Tsu-Yuan Cheng, Ming-Che Hsu, Yu-Chi CHIA-CHUAN CHANG |
關鍵字: | Anti-inflammatory effects; Antiproliferation; Antrodia cinnamomea; Sulfated polysaccharides | 公開日期: | 30-六月-2023 | 卷: | 241 | 起(迄)頁: | 124559 | 來源出版物: | International journal of biological macromolecules | 摘要: | A sulfated galactoglucan (3-SS) was discovered in Antrodia cinnamomea with antiproliferative and anti-inflammatory activities. Chemical identification of 3-SS resulted in the determination of a partial repeat unit as a 2-O sulfated 1,3-/1,4-linked galactoglucan with a two-residual 1,6-O-β-Glc branch on the 3-O position of a Glc. by monosaccharide analysis and 1D and 2D NMR spectroscopy. The anti-inflammation effects of 3-SS on RAW264.7 macrophage cells, such as IL-6 inhibition, restoration of LPS-induced IκB protein degradation, and inhibited LPS-induced TGFRII protein degradation, were confirmed to occur via AKT, ERK1/2, and p-38. In addition, 3-SS impaired the proliferation of H1975 lung cancer cells through EGFR/ERK/slug signaling. This is the first finding of 2-O sulfated 1,3-/1,4-galactoglucan with 1,6-β-Glc branches with dual functions of anti-inflammatory and antiproliferative activities. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641301 | ISSN: | 01418130 | DOI: | 10.1016/j.ijbiomac.2023.124559 |
顯示於: | 藥學系 |
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