https://scholars.lib.ntu.edu.tw/handle/123456789/641303
標題: | Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana | 作者: | Lu, Ching Yi Huang, Zheng Ying Chen, Meng Chin Liu, Hui Kang SHOEI-SHENG LEE CHIA-CHUAN CHANG |
關鍵字: | Boehmeria formosana | GLP-1-enhancing ability | Phenanthroindolizidine alkaloids | Secondary metabolites | α-glucosidase inhibitor | 公開日期: | 1-一月-2023 | 卷: | 31 | 期: | 4 | 起(迄)頁: | 739 | 來源出版物: | Journal of Food and Drug Analysis | 摘要: | Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5-and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641303 | ISSN: | 10219498 | DOI: | 10.38212/2224-6614.3483 |
顯示於: | 藥學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。