https://scholars.lib.ntu.edu.tw/handle/123456789/641360
標題: | Intramolecular Heck cyclization to the galanthamine-type alkaloids: Total synthesis of (±)-lycoramine | 作者: | PI-HUI LIANG Liu, Jing Ping LING-WEI HSIN Cheng, Chen Yu |
關鍵字: | Galanthamine | Heck reaction | Intramolecular cyclization | Lycoramine | 公開日期: | 6-十二月-2004 | 卷: | 60 | 期: | 50 | 起(迄)頁: | 11655 | 來源出版物: | Tetrahedron | 摘要: | A novel approach towards the construction of the galanthamine skeleton was demonstrated by the total synthesis of (±)-lycoramine. The key steps include a Pd-catalyzed intramolecular cyclization to form the seven-membered azepane ring and a spontaneous intramolecular Michael addition to afford the five-membered furan ring. This synthetic route has also been demonstrated to be useful for the preparation of novel derivatives with simplified galanthamine skeletons. Graphical Abstract. © 2004 Elsevier Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641360 | ISSN: | 00404020 | DOI: | 10.1016/j.tet.2004.09.044 |
顯示於: | 藥學系 |
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