https://scholars.lib.ntu.edu.tw/handle/123456789/641387
標題: | New noninvasive index for predicting liver fibrosis in Asian patients with chronic viral hepatitis | 作者: | Wang, Hung-Wei Peng, Cheng-Yuan Lai, Hsueh-Chou Su, Wen-Pang Lin, Chia-Hsin Chuang, Po-Heng Chen, Sheng-Hung Chen, Ching-Hsiang Hsu, Wei-Fan GUAN-TARN HUANG |
公開日期: | 12-六月-2017 | 卷: | 7 | 期: | 1 | 起(迄)頁: | 3259 | 來源出版物: | Scientific reports | 摘要: | We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (mFIB-4) according to four independent variables of the model: age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet count. The formula of the mFIB-4 index is 10 × Age(years) × AST(U/L)/Platelet count(109/L) × AST(U/L). For predicting cirrhosis, the bootstrap areas under the receiver operating characteristic curve for platelet count, AST/ALT ratio (AAR), AAR/platelet ratio index (AARPRI), AST/platelet ratio index (APRI), FIB-4, Pohl score, age-platelet (AP) index, Lok index, fibrosis quotient (FibroQ), and mFIB-4 were 0.7680, 0.7400, 0.8070, 0.6090, 0.7690, 0.6990, 0.7850, 0.7960, 0.8110, and 0.8070 in CHB patients, and 0.8170, 0.7210, 0.8400, 0.7310, 0.8310, 0.6730, 0.8220, 0.8440, 0.8570, and 0.8480 in CHC patients, respectively. FibroQ and mFIB-4 exhibited the highest diagnostic performance levels for liver cirrhosis in CHB and CHC despite the inclusion of the international normalised ratio in the formulation of FibroQ. Thus, mFIB-4 is a simple, inexpensive, and readily available method for assessing the liver fibrosis stage of Asian patients with CHB or CHC. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85020741031&doi=10.1038%2fs41598-017-03589-w&origin=inward&txGid=82303c90161ea4de9e564f413a6f511c https://scholars.lib.ntu.edu.tw/handle/123456789/641387 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-03589-w |
顯示於: | 醫學系 |
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