https://scholars.lib.ntu.edu.tw/handle/123456789/641429
標題: | The FIB-4 scores in the emergency department to predict the outcomes of COVID-19 patients in taiwan | 作者: | Liu, Chia Yu Chou, San Fang Chiang, Pei Ying Sun, Jen Tang Tsai, Kuang Chau FU-SHAN JAW Chang, Chung Ta Fan, Chieh Min Wu, Yuan Hui Lee, Peng Yu Hsieh, Chia Ying Chen, Jie Ming Hsieh, Chien Chieh |
關鍵字: | COVID-19 | Critical care medicine | Respiratory distress | 公開日期: | 29-二月-2024 | 卷: | 10 | 期: | 4 | 來源出版物: | Heliyon | 摘要: | Objective: We aimed to determine the reliability of using the Fibrosis-4 (FIB-4) index in COVID-19 patients without underlying liver illness. Method: We employed multivariate logistic regression to identify variables that exhibited statistically significant influence on the ultimate outcome. Multilayer perceptron analysis was employed to develop a prediction model for the FIB-4 index concerning ICU admission and intubation rates. However, the scarcity of cases rendered the assessment of the mortality rate unfeasible. We plotted ROC curves to analyze the predictive strength of the FIB-4 index across various age groups. Result: In univariate logistic regression, only the FIB-4 index and respiratory rate demonstrated statistical significance on all poor outcomes. The FIB-4 index for mortality prediction had an ROC and AUC of 0.863 (95% CI: 0.781–0.9444). It demonstrates predictive power across age groups, particularly for age ≥65 (AUC: 0.812, 95% CI: 0.6571–0.9673) and age <65 (AUC: 0.878, 95% CI: 0.8012–0.9558). Its sensitivity for intubation and ICU admission prediction is suboptimal. Conclusion: FIB-4 index had promising power in prediction of mortality rate in all age groups. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641429 | ISSN: | 24058440 | DOI: | 10.1016/j.heliyon.2024.e25649 |
顯示於: | 醫學工程學研究所 |
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