https://scholars.lib.ntu.edu.tw/handle/123456789/641488
標題: | Safety, Tolerability, and Immunogenicity of Booster Dose with MVC-COV1901 or MVC-COV1901-Beta SARS-CoV-2 Vaccine in Adults: A Phase I, Prospective, Randomized, Open-Labeled Study | 作者: | Lien, Chia En Liu, Ming-Che Wang, Ning-Chi Liu, Luke Tzu-Chi Wu, Chung-Chin Tang, Wei-Hsuan Lian, Wei-Cheng Kuan-Ying A. Huang Chen, Charles |
關鍵字: | COVID-19; MVC-COV1901; SARS-CoV-2 vaccine; booster vaccination | 公開日期: | 1-十二月-2023 | 出版社: | MDPI | 卷: | 11 | 期: | 12 | 來源出版物: | Vaccines | 摘要: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines based on variant strains have been in use as booster doses to update immunity against circulating variants. Here we present the results of a phase one prospective, randomized, and open-labeled trial to study the safety and immunogenicity of a booster dose consisting of a subunit vaccine based on the stabilized prefusion SARS-CoV-2 spike protein, MVC-COV1901, or its Beta version, MVC-COV1901-Beta. Participants aged ≥18 and <55 years who received two or three prior doses of MVC-COV1901 vaccines were enrolled and were to receive a booster dose of either 15 mcg of MVC-COV1901, 15 mcg, or 25 mcg of MVC-COV1901-Beta in a 1:1:1 ratio. Adverse reactions after either MVC-COV1901 or MVC-COV1901-Beta booster doses after two or three doses of MVC-COV1901 were comparable and mostly mild and transient. At four weeks after the booster dose, participants with two prior doses of MVC-COV1901 had higher levels of neutralizing antibodies against ancestral SARS-CoV-2, Beta, and Omicron variants than participants with three prior doses of MVC-COV1901, regardless of the type of booster used. MVC-COV1901 and MVC-COV1901-Beta can both be effectively used as booster doses against SARS-CoV-2, including the BA.4/BA.5 Omicron variants. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641488 | ISSN: | 2076-393X | DOI: | 10.3390/vaccines11121798 |
顯示於: | 免疫學研究所 |
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