https://scholars.lib.ntu.edu.tw/handle/123456789/641541
標題: | Allogeneic hematopoietic stem cell transplantation for B-cell lymphoma in Taiwan | 作者: | Lee, Chun-Hui Lin, Tzu-Chien MING YAO Hsiao, Liang-Tsai BOR-SHENG KO Liu, Chia-Jen Chen, Tsai-Yun |
關鍵字: | B-cell lymphoma; complete remission; diffuse large B-cell lymphoma; hematopoietic stem cell transplantation; relapse and refractory | 公開日期: | 十二月-2023 | 卷: | 12 | 期: | 24 | 起(迄)頁: | 21761 | 來源出版物: | Cancer medicine | 摘要: | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered for patients with high-risk B-cell lymphoma and relapsed or refractory disease. This study aimed to analyze the long-term follow-up data of patients who underwent allo-HSCT in Taiwan. This was a retrospective observational study using data from the Taiwan Society of Blood and Marrow Transplantation database. A total of 105 patients who underwent allo-HSCT because of high-risk, relapsed, or refractory disease between 2010 and 2019 were included. Forty-five percent of the patients previously underwent autologous stem cell transplantation (ASCT). The median follow-up duration was 18.6 months. The probability of 3-year progression-free survival and overall survival (OS) was 34.5% and 37%, respectively. The probability of 1-year non-relapse mortality was 31.4%, and the major cause was infection (75.8%). The multivariable analysis showed that not in remission at the time of transplantation and the absence of graft-versus-host disease (GVHD) were factors associated with inferior OS. The probability of 3-year OS in patients with diffuse large B-cell lymphoma who underwent allo-HSCT and allo-HSCT after ASCT was 40.2% and 25.2%, respectively. Allo-HSCT could be a salvage therapeutic option for relapsed or refractory B-cell lymphoma. Complete remission at the time of allo-HSCT and the presence of GVHD are independent variables for overall survival. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85178185604&doi=10.1002%2fcam4.6741&origin=inward&txGid=345e631d413b93cf766dda1b9a03a095 https://scholars.lib.ntu.edu.tw/handle/123456789/641541 |
ISSN: | 2045-7634 2045-7634 |
DOI: | 10.1002/cam4.6741 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。