https://scholars.lib.ntu.edu.tw/handle/123456789/641641
標題: | Craniofacial and olfactory sensory changes after long-term unilateral nasal obstruction-an animal study using MMP-3-LUC transgenic rats | 作者: | Hsu, Li-Fang Ratanasereeprasert, Nutthakarn SHIH-KAI WANG JUNG-TSU CHEN YI-JANE CHEN TE-HUEI YEH Sung, Hsiang-Hsuan JANE CHUNG-CHEN YAO |
公開日期: | 31-一月-2024 | 卷: | 14 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Nasal obstruction exerts considerable physiological effects on the respiratory system and craniofacial morphology during the developmental stage. This study used MMP-3-LUC transgenic rats for in vivo tracking of long-term expression in the rat nasal region after unilateral nasal obstruction. Skeletal changes of the craniofacial, nasal, and sinus regions were measured through micro-computed tomography examination and analysis with 3D image processing and calculation. Matrix metalloproteinase-3 and olfactory marker protein expression were also investigated through immunohistochemistry (IHC). Unilateral nasal obstruction significantly reduced the MMP-3 signal in the nasal region of MMP-3-LUC transgenic rats, which was mainly expressed in the respiratory epithelium. Long-term obstruction also caused morphological changes of the craniofacial hard tissue, such as nasal septal deviation, longer inter-jaw distance, and increased maxillary molar dental height. It also caused compensatory growth in olfactory nerve bundles and the olfactory epithelium, as confirmed by IHC. In our study, long-term unilateral nasal obstruction caused nasal septal deviation toward the unobstructed side, hyper divergent facial development including longer molar dental height, and reduced MMP-3 production. However, further investigation is necessary to explore the mechanism in depth. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641641 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-024-51544-3 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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