https://scholars.lib.ntu.edu.tw/handle/123456789/641659
標題: | Temporal changes in biomarkers of neutrophil extracellular traps and NET-promoting autoantibodies following adenovirus-vectored, mRNA, and recombinant protein COVID-19 vaccination | 作者: | YU-MIN KUO CHUN-MIN KANG Lai, Zhi-Yun Huang, Ting-Yu SHIANG-JONG TZENG Hsu, Chih-Chieh SHEY-YING CHEN SONG-CHOU HSIEH JEAN-SAN CHIA Jung, Chiau-Jing PO-REN HSUEH |
關鍵字: | ChAdOx1 nCoV‐19; MVC‐COV1901 vaccine; autoantibodies; mRNA‐1273.211; neutrophil extracellular traps | 公開日期: | 三月-2024 | 卷: | 96 | 期: | 3 | 來源出版物: | Journal of medical virology | 摘要: | Neutrophil extracellular traps (NETs) play a role in innate pathogen defense and also trigger B-cell response by providing antigens. NETs have been linked to vaccine-induced thrombotic thrombocytopenia. We postulated a potential link between NET biomarkers, NET-promoting autoantibodies, and adverse events (AEs) after COVID-19 vaccine boosters. Healthy donors (HDs) who received ChAdOx1-S (A), mRNA-1273 (M), or recombinant protein (MVC-COV1901) vaccines at the National Taiwan University Hospital between 2021 and 2022 were recruited. We measured serial NET-associated biomarkers, citrullinated-histone3 (citH3), and myeloperoxidase (MPO)-DNA. Serum citH3 and MPO-DNA were significantly or numerically higher in HDs who reported AEs (n = 100, booster Day 0/Day 30, p = 0.01/p = 0.03 and p = 0.30/p = 0.35, respectively). We also observed a positive correlation between rash occurrence in online diaries and elevated citH3. A linear mixed model also revealed significantly higher citH3 levels in mRNA-1273/ChAdOx1-S recipients than MVC-COV1901 recipients. Significant positive correlations were observed between the ratios of anti-heparin platelet factor 4 and citH3 levels on Booster Day 0 and naïve and between the ratios of anti-NET IgM and citH3 on Booster Day 30/Day 0 in the AA-M and MM-M group, respectively. The increased levels of citH3/MPO-DNA accompanied by NET-promoting autoantibodies suggest a potential connection between mRNA-1273/ChAdOx1-S vaccines and cardiovascular complications. These findings provide insights for risk assessments of future vaccines. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641659 | ISSN: | 0146-6615 1096-9071 |
DOI: | 10.1002/jmv.29556 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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