https://scholars.lib.ntu.edu.tw/handle/123456789/642475
標題: | A retrospective study of chemotherapeutic effect without wide-margin surgery or radiation therapy in dogs with oral malignant melanoma | 作者: | Xia, Yuanyuan TAI-CHING LIAO JIH-JONG LEE |
公開日期: | 1-四月-2024 | 卷: | 65 | 期: | 4 | 來源出版物: | The Canadian veterinary journal = La revue veterinaire canadienne | 摘要: | Background: Effective treatment for canine oral malignant melanoma (e.g., curative-intent surgery) may not be feasible or radiation therapy may be unavailable. However, chemotherapy is usually an option, and more information is needed regarding its use without adequate local treatments. Objective: Our objective was to investigate the efficacy of chemotherapy in canine oral malignant melanoma without adequate local control, using carboplatin with dose reduction in small-breed dogs and metronomic chemotherapy. Animals and procedure: Client-owned dogs with histopathologically diagnosed oral malignant melanoma were retrospectively enrolled from 2016 to 2022. The chemotherapy protocol in each case was determined by the attending clinician. Results: Thirteen dogs were included. The median progression-free interval of all 13 dogs was 42 d (14 to 953 d). The median overall survival time of dogs with chemotherapy as their only systemic treatment was 181 d (50 to 960 d; n = 11). The median dosage of carboplatin was 250 mg/m2. Response to treatment and clinical stage were significant prognostic factors. Conclusion and clinical relevance: As chemotherapy provided a median survival of 6 mo, it could be considered when adequate local control is infeasible. Earlier clinical stages or achievement of at least stable disease during chemotherapy may indicate better survival in dogs. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189794608&partnerID=40&md5=75966484597cb4c09995c752415728ce https://scholars.lib.ntu.edu.tw/handle/123456789/642475 |
ISSN: | 00085286 |
顯示於: | 獸醫學系 |
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