https://scholars.lib.ntu.edu.tw/handle/123456789/83293
標題: | 麻醉模型之建立 | 作者: | 趙福杉 | 關鍵字: | 血壓;麻醉;大鼠;自動控制;blood pressure;anesthesia;rat;automatic control | 公開日期: | 31-七月-2001 | 出版社: | 臺北市:國立臺灣大學醫學工程學研究所 | 摘要: | 本計畫以大鼠麻醉自動監控系統,透 過視窗圖形操作介面來量測血壓波形、腦 電圖及控制注射幫浦給藥,並分析血壓波 參數隨著大鼠麻醉深度增加之變化,及麻 醉深度與大鼠體重、麻藥濃度關係,以建 立其數學模型。結果顯示血壓隨著麻醉深 度之增加而降低,其次麻醉致死所需之時 間與大鼠體重呈指數之正比關係,而與麻 藥濃度呈反比之關係。對體重及濃度做正 規化之結果可以得到類似的曲線,若再將 其做進一步的整合,應可得到一曲線範本 (template),進而掌握大鼠體重、麻藥濃度 對麻醉過度致死過程的影響。 An automatic system was designed for the control and mornitoring of the anesthetic depth of the rat. This window-based system is capable of measuring blood pressure (BP) and electroencephagram (EEG), and controlling the drug delivery by an infusion pump. To understand mechanisms involved in anesthesia, the changes of BP, the effects of body weight of the experiment animals, and the concentration of the anesthetic agent during an experiment were recorded. Later analysis shows that the BP decays as the depth of anesthesia increases. The time needed for a rat to die due to overdose of anesthesia is proportionally increased as the rat's body weight increases in an exponential manner. On the other hand, such a time is inversely proportional to the concentration of the anesthetic drug. It is suggested that a conbined curve template may be an adequate index for the monitoring of anesthetic level. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/22354 | 其他識別: | 902213E002060 | Rights: | 國立臺灣大學醫學工程學研究所 |
顯示於: | 醫學工程學研究所 |
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902213E002060.pdf | 152.51 kB | Adobe PDF | 檢視/開啟 |
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