https://scholars.lib.ntu.edu.tw/handle/123456789/83560
Title: | Immobilization of chitosan gel with cross-linking reagent on PNIPAAm gel/PP nonwoven composites surface | Authors: | Chen, Ko-Shao Ku, Yuan-An Lee, Chi-Han Lin, Hong-Ru Lin, Feng-Huei Chen, Tim-Mo |
Keywords: | Biocompatibility; Chitosan; Plasma; Poly(N-isopropylacrylamide); PP nonwoven | Issue Date: | 2005 | Journal Volume: | 25 | Journal Issue: | 4 | Start page/Pages: | 472-478 | Source: | Materials Science and Engineering: C | Abstract: | This study was to immobilize chitosan (CS), which is a biodegradable and antibacterial polymer, on poly(N-isopropylacrylamide) (PNIPAAm) gel/polypropylene (PP) nonwoven composites surface for wound dressing applications. PP nonwoven has been extensively used due to its porosity, allowing ventilation, high surface area and excellent mechanical properties. However, the hydrophobic surface of PP nonwoven limits its applications; in this study, we used the plasma-activation treatment and subsequently UV-light graft polymerization of NIPAAm gel to improve its hydrophilicity. Chitosan was immobilized onto PNIPAAm gel/PP nonwoven composites surface using the cross-linking agent, glutaraldehyde (GA). This complex was characterized by scanning electron microscopy (SEM). The results indicated that the wettability of the composite was improved after plasma treatment and photo-induced graft polymerization and chitosan was successfully immobilized onto the surface of PNIPAAm gel/PP nonwoven composites through cross-linking process. Finally, the preliminary result shows that chitosan hydrogels displayed antibacterial ability to Escherichia coli and Staphylococcus aureus. The (3-(4, 5-dimethylthiazolyl- 2)-2, 5-diphenyltetrazolium bromide) (MTT) method indicated that the porous chitosan sponge exhibited good biocompatibility to fibroblast cells. © 2005 Elsevier B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/128015 https://www.scopus.com/inward/record.uri?eid=2-s2.0-23144458661&doi=10.1016%2fj.msec.2004.12.006&partnerID=40&md5=bcd1f1bd8f45dc5dd78c91871269c2dd |
ISSN: | 09284931 | SDG/Keyword: | Biocompatibility; Biodegradation; Crosslinking; Gels; Hydrogels; Hydrophobicity; Plasmas; Polymers; Porous materials; Scanning electron microscopy; Chitosan; Fibroblast cells; Poly(N-isopropylacrylamide); PP nonwoven; Composite materials |
Appears in Collections: | 醫學工程學研究所 |
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