|Title:||Dual Chemotherapy and Photodynamic Therapy in an Ht-29 Human Colon Cancer Xenograft Model Using Sn-38-Loaded Chlorin-Core Star Block Copolymer Micelles||Authors:||PENG, CHENG-LIANG
WU, STEVEN YUEH-HSIU
|Keywords:||Star-shaped copolymer;Micelle;Photodynamic therapy;SN-38;Chemotherapy;Colon cancer||Issue Date:||2009||Start page/Pages:||3614-3625||Source:||Biomaterials||Abstract:||
Chlorin-core star-shaped block copolymer (CSBC) may self- assemble to form micelles, which act as nanosized photosensitizing agents for photodynamic therapy (PDT) and further encapsulate hydrophobic drugs. This functionalized micellar delivery system is a potential dual carrier for the synergistic combination of photodynamic therapy and chemotherapy for the treatment of cancer. In this study, SN- 38 encapsulated CSBC micelles were successfully prepared using a lyophilization-hydration method. Our results show that the prolonged plasma residence time of SN-38/CSBC micelles as compared with free CPT-11 permit increased tumor accumulation and consequently, improved antitumor activity. The combined effects of SN- 38/CSBC micelles with PDT were evaluated in an HT-29 human colon cancer xenograft model. Interesting, SN-38/CSBC-mediated PDT synergistically inhibited tumor growth, resulting in up to 60% complete regression of well -established tumors after 3 treatments. These treatments also decreased the microvessel density (MVD ) and cell proliferation within the subcutaneous tumors. Therefore, this SN-38/CBSC delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer.
|Appears in Collections:||醫學工程學研究所|
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