https://scholars.lib.ntu.edu.tw/handle/123456789/84218
標題: | Quantitative Pinch Stimulator for Exploring Evoked Nociceptive Responses: A Pilot Study | 作者: | Chen, Chih-Ping Liao, Wen-Li Tseng, Yi-Li Lu, Pen-Li Lo, Yu-Chun Chen, You-Yin Jaw, Fu-Shan |
公開日期: | 2010 | 起(迄)頁: | 79 | 來源出版物: | BioMedical Engineering OnLine | 摘要: | Background: A mechanical noxious stimulator is useful for studies of pain , both for clinic and basic research. We propose to use a pinch stimulator that can not only generate a quantitative, reproducible noxious pinch but also simultaneously provide a synchronous external trigger signal , which is essential for acquisition of evoked potentials. Methods: For ethical considerations, audible and visual aids were incorporated so that pinch force could be regulated within a predetermined level. Reproducibility of the nociceptive responses evoked by this device was validated. The device was constructed with a simple circuit, and the element build-in was delicately selected for the minimum required to produce evoked potentials. Results: The magnitude of the force output is linearly proportional to the volts produced by the device i.e., during the pinch. Increases in force correspond to increases in the number of action potentials induced. Conclusions: This device may be useful for studying the mechanisms of nociceptive signal processing in the brain through application of reproducible, noxious pinch stimuli. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/242014 | DOI: | 10.1186/1475-925X-9-79 | SDG/關鍵字: | Pilot studies; Action potentials; Basic research; Ethical considerations; Linearly proportional; Pilot studies; Reproducibilities; Simple circuits; Visual aids; animal; article; electrical equipment; evoked response; male; pain; pathophysiology; physiology; pilot study; rat; somatosensory cortex; Wistar rat; Animals; Electrical Equipment and Supplies; Evoked Potentials; Male; Pain; Pilot Projects; Rats; Rats, Wistar; Somatosensory Cortex; Communication; Electrophysiology; Signal processing |
顯示於: | 醫學工程學研究所 |
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