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    Management of Metastatic Urothelial Carcinoma in Emerging Markets (EM): An Expert Opinion.
    (2024-04)
    Soares, Andrey
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    Bourlon, Maria T
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    Wong, Alvin
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    Joshi, Amit
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    Jardim, Denis
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    Korbenfeld, Ernesto
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    Karak, Fadi El
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    Orlandi, Francisco
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    Sze, Henry
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    Ansari, Jawaher
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    Zarba, Jose
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    Mansour, Mubarak Al
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    Manneh, Ray
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    Thirumulai, Raja
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    Morsi, Waleed Al
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    Powles, Thomas
    Urothelial carcinoma (UC) is the 10 most common cancer globally with an almost 4 times higher prevalence in men. The main risk factors for development of urothelial carcinoma are advanced age, smoking, arsenic contamination, exposure to carcinogens. Metastatic urothelial carcinoma (mUC) has overall poor prognosis with a 5-year overall survival rate of only < 5%. The standard of care comprises of platinum-based chemotherapy, but the responses are often not sustained. A working group was established with an objective to discuss the most recent clinical data on the genitourinary tumors of interest and comprised of experts across Latin America, Emerging Asia (except China, Japan, and South Korea), Africa, and the Middle East (known as Emerging Markets or EM). There is an evident disparity in terms of uneven mortality and incidence rate distribution among various regions. There is a lack and/or insufficient data on epidemiology, treatment, and outcomes in the EM. The lack of registries impacts the healthcare decisions and the lower incidence from the region might not be reflective of the true disease burden. The treatment outcomes of mUC can be improved by understanding the current disease burden and treatment approach of mUC and identifying the gaps and challenges associated with management. Hence, a literature review was developed to summarize the current disease burden and treatment approach of mUC across EM. The review also highlights the unmet needs for mUC management in EM and suggests a way forward to improve the current situation in order to better serve the patients.
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    Interrelationships between physical multimorbidity, depressive symptoms and cognitive function among older adults in China, India and Indonesia: A four-way decomposition analysis
    (Elsevier, 2024)
    Anindya, K.
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    Zhao,Yang
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    Thanh Hoang
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    Sanjay Juvekar
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    Anand Krishnan
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    Vanessa Mbum
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    Tarishi Sharma
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    Nawi Ng
    Objective This paper explores the role of depressive symptoms (mediator/moderator) in the association between physical multimorbidity (exposure) and cognitive function (outcome) among older adults in the three most populous middle-income countries. Methods This study used cross-sectional data from China (2015 China Health and Retirement Longitudinal Study), India (2017/2018 Longitudinal Ageing Study in India), and Indonesia (2014/2015 Indonesian Family Life Survey), with a total sample of 73,199 respondents aged ≥ 45 years. Three domains of cognitive tests were harmonised across surveys, including time orientation, word recall, and numeracy. The four-way decomposition analysis assessed the mediation and interaction effects between exposure, mediator/moderator, and outcome, adjusted for covariates. Results The mean age of the respondents (in years) was slightly younger in Indonesia (56.0, SD = 8.8) than in China (59.5, SD = 9.3) and India (60.0, SD = 10.5). The proportion of male respondents was 49.3 % in China, 47.3 % in India, and 47.5 % in Indonesia. Respondents in China had the highest mean cognitive function z scores (54.7, SD = 19.9), followed by India (51.1, SD = 20.0) and Indonesia (51.0, SD = 18.4). Physical multimorbidity was associated with lower cognitive function in China and India (p < 0.0001), with 48.4 % and 40.0 % of the association explained by the mediating effect of depressive symptoms (‘overall proportion due to mediation’). The association was not found in Indonesia. Conclusion Cognitive functions were lower among individuals with physical multimorbidity, and depressive symptoms mainly explained the association. Addressing depressive symptoms among persons with physical multimorbidity is likely to have not only an impact on their mental health but could prevent cognitive decline.
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    Long-term results of stereotactic arrhythmia radioablation for refractory ventricular Arrhythmias-A Taiwanese population study.
    (2024-12-02)
    Ho, Li-Ting
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    Chen, Jenny Ling-Yu
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    Hsu, Jung-Chi
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    Chan, Hsing-Min
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    Huang, Yu-Cheng
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    Su, Mao-Yuan
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    Chang, Yeun-Chung
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    Lin, Jiunn-Lee
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    Chen, Wen-Jone
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    Lee, Wen-Jeng
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    Juang, Jyh-Ming Jimmy
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    Lin, Lian-Yu
    Stereotactic arrhythmia radioablation (STAR) has proven to be effective in refractory ventricular tachyarrhythmia (VT). We report the long-term results in first Asian series of STAR for refractory VT in a group of Taiwanese.
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    A method to obtain optimal relative electron densities of metallic samples for a density scaling-based commercial photon dose calculation algorithm
    (2025-04-01)
    Lin C.S.
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    Tsai, Yi-Chun
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    Wang, Chun-Wei
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    Chen, Liang-Hsin
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    Lu, Hsiang-Chin
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    Lin, Tsung-Yu
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    Wu, Chia-Jung
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    Wei, Li-Chien
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    Liang, Hsiang-Kung
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