Browsing by Author "Chan C.-C"

The standard medical practice for cancer diagnosis requires histopathology, which is an invasive and time-consuming procedure. Optical coherence tomography (OCT) is an alternative that is relatively fast, noninvasive, and able to capture three-dimensional structures of epithelial tissue. Unlike most previous OCT systems, which cannot capture crucial cellular-level information for squamous cell carcinoma (SCC) diagnosis, the full-field OCT (FF-OCT) technology used in this paper is able to produce images at sub-micron resolution and thereby facilitates the development of a deep learning algorithm for SCC detection. Experimental results show that the SCC detection algorithm can achieve a classification accuracy of 80% for mouse skin. Using the sub-micron FF-OCT imaging system, the proposed SCC detection algorithm has the potential for in-vivo applications. ? 2020 Wiley-VCH GmbH

Weakly supervised conversion from in vivo OCT images on human skin to H&E-stain-like images is developed. The dermis-epidermis junction, stratum corneum boundary, and nuclei distribution match well between the OCT and converted H&E-stain-liked images. ? 2020 The Author(s)