The research projects in our department are generally diverse, including tumor research, biochemistry, mouse model, microbiology and immunology.
For tumor research, finding molecular biomarkers is one of the major goals, not only for diagnostic values, but also for the prediction of the treatment outcome, we have found markers in acute myeloid leukemia and colorectal carcinoma.
Another project focuses on microRNAs. We identify a 5-gene signature and a 5-microRNA signature that are independent predictors of cancer recurrence and overall survival of lung cancer patients. Both signatures may have prognostic or therapeutic implications for the future management of lung cancer patients.
One project is investigating natural compounds for apoptosis, senescence, or autophage in cancer cells via influences on cell signaling molecules. For mouse models, using gene knockout mice we have studied coagulation protein function, platelet functions in cardiovascular disease, cancer metastasis, and development, etc. and also set up a National Gene Knockout Mouse Core Laboratory since 2005.
For biochemistry, major research interests include hypertriglyceridemic genomics, translational research related to personalized therapy of hypertriglyceridemia, mismatch repair and mutagenesis.
For microbiology, we focus pathogenesis, gene regulation, drug resistance, laboratory diagnosis and molecular epidemiology in bacteria (Staphylococcus, Streptococcus, Proteus, etc.), yeast (Saccharomyces) and viruses (rotavirus, enterovirus 71, dengue virus, human immunodeficiency virus type 1, etc.).
For immunology part, the research interests are immune regulation and immunotherapy of autoimmune diseases and allergic diseases. Recently, our research focuses on the role of invariant NKT (iNKT) cells in primary biliary cirrhosis (PBC) and allergic asthma.