Our major research fields are as follows:
- Search for agents against ischemia reperfusion heart injury, sepsis and diabetes.
- Systemic study on the mechanism of the anti-thrombotic agents and investigate the effects of snake venom components on blood coagulation.
- Discovering the anti-angiogenesis agents by investigating their effects on the proliferation and differentiation of vascular endothelial cells and smooth muscle cells.
- Search for the potential candidates to treat neuron degeneration diseases, including stroke, epilepsy, Parkisonism, Alzheimer's disease, pain sensation, neuron plasticity.
- Two novel neuropeptide systems (nociceptin/orphanin FQ and orexins/hypocretinis) are actively explored to investigate the molecular mechanism for several neural functions, including spinal analgesia, hyperphagia, depression, anxiolytic, hypolocomotion and learning and memory.
- Characterize the functions and signaling cascades of pathogen receptors (e.g. TLR, NOD-like receptor and C-type lectin receptors)
- Investigate the FcγRIIB signaling cascade to delineate the molecular basis of immune tolerance and discover the treatment of autoimmune disease.
- Search for the potential targets for cancer therapy
- Investigate the molecular pathways and epigenetic regulation that lead to the tumorigenesis and metastasis
- Explore the signal regulating pathways and intracellular mediators leading to cell death (e.g. apoptosis, necrosis and autophagic cell death)
- Investigate the pharmacological mechanisms of anti-cancer agents (e.g. natural products, synthetic compounds)
Stem cell biology
- Establish the culture system to identify stem/progenitor cell population in different tissues
- Utilizing the regenerative capacity of stem cells to develop and repair tissues and organs