Abstract
摘要：本兩年期研究計畫（97-98年度）旨在研發新型複合導電高分子奈米修飾電極以增進還原態菸鹼醯胺腺嘌呤二核苷酸（NADH）之氧化電催化速率，進而提升脫氫酵素型酒精感測器及酒精生物燃料電池之電流效率。其整體研發內容涵蓋 (i) 導電高分子奈米複合材料；(ii) NADH電催化；(iii) 高靈敏度酒精感測酵素電極；(iv) 高效率酵素型乙醇/氧氣生物燃料電池；(v) 生物電子元件微小化相容技術；(vi) 生質酒精製程應用及生醫檢測等六大項目。計畫執行的第一年將以「高NADH催化活性之導電高分子奈米修飾材料開發」為目標。有鑑於azine衍生物（如methylene blue）能有效降低NADH氧化過電位，且奈米結構和奈米觸媒能促進電催化反應，因此本年度將探究下列兩大課題：(i) polyazine導電高分子電聚合與其奈米結構製備；(ii) 比較不同複合導電高分子奈米修飾電極之NADH電催化性能及奈米觸媒摻雜效應。基於第一年之成果，計畫第二年將以「高電流效率酒精生物電子元件組裝與應用」為研發目標，具體內容為 (i) 導線架構奈米脫氫酵素電極研製；(ii) 高敏度酒精感測器製備與生質酒精研發應用；(iii) 高效率酵素型酒精燃料電池開發與微小化技術發展。本計畫團隊期待藉由奈米科學、高分子科技及電化學技術之整合，增進生物電子元件之發展及實用價值。
Abstract: This two-year (2008/8-2010/7) research project aims to develop novel chemically modified electrodes based on conducting polymer nanocomposites to accelerate the electrocatalytic oxidation of NADH (the reduced form of nicotinamide adenine dinucleotide) and thereby to enhance the current efficiency of dehydrogenase-based alcohol sensors and biofuel cells. The goals of this project include (i) preparation of conducting polymer nanocomposite materials, (ii) study of electrocatalytic NADH oxidation, (iii) fabrication of high-sensitivity alcohol sensing electrodes, (iv) assembly of high-efficiency ethanol/O2 biofuel cells, (v) development of miniaturization-compatible techniques for bioelectronic devices, and (vi) applications to bioethanol process and biomedical detection. We will target at “exploiting new conducting polymer nanocomposites for attaining high NADH electrocatalytic activity” in the first year. It is known that azine derivatives (such as methylene blue) can effectively lower the overpotential of NADH electro-oxidation. In addition, nanostructures and nanocatalysts can enhance the electrocatalytic reaction presumably. Accordingly, we plan to (i) investigate electropolymerization and nanostructure fabrication of polyazine conducting polymers and (ii) compare NADH electrocatalytic characteristics of different polyazine nanocomposite modified electrodes. On the basis of the first year findings, we target at “assembly and applications of high current-efficiency alcohol bioelectronic devices” in the second year. That will cover (i) preparation of wired nano-dehydrogenase electrodes, (ii) fabrication of high-sensitivity alcohol sensors and applications to bioethanol research, and (iii) development of high-efficiency enzymatic alcohol fuel cells and miniaturization techniques. To sum up, this project aims to promote the development and viability of bioelectronic devices through the integration of interdisciplinary nanosciences, polymer technologies, and electrochemical approaches.
Keyword(s)
酒精感測器
生物燃料電池
導電高分子奈米複合材料
電催化
菸鹼醯胺腺嘌呤二核苷
酸
Alcohol sensors
biofuel cells
conducting polymer nanocomposites
electrocatalysis
nicotinamide adenine dinucleotide
