Abstract: The cell migration is one of the most important phenomenons in cell biology. It directly affects wound healing, tissue regeneration, and tumor cell metastasis. As a consequence, it is intriguing to employ nanotechnologies to study this cell behavior. Utilizing nanotechnologies, not only chemical/mechanical cue can be studied but also photo-induced mechanism can be explored. This will not only offer the fundamental understanding of tissue regeneration but also give us the insight of cancer cell development. To achieve above ambitious goals, we will develop opto-electronic biochip as the cell analysis platform.
Traditionally, the cell migration study is accomplished in cell culture dishes. Recently, the micro-environmental effect has also been studied in microfluidic channel based on the advancement of micro-fabrications. However, few of studies explore the photo-induced cell migration and non-contact cue of cell migration. Because of the limitation measurement tools, in addition, it is rarely to study these factors in traditional cell migration assays. To overcome these obstacles, we will fabricate the cell chip to study the photo-induced cell migration phenomena of cancer cells. This will integrate the traditional understandings of cell biology and innovative applications of infra-red nanotechnologies. Moreover, the developed cell chip can be stimulated and monitored by both optical and electrical methods under well-controlled microenvironments. Utilizing the developed cell monitoring platform, the tumor cell will be used as the cell model to study the cell migration phenomena affected by chemical, mechanical, and photonic cues. The result of this study can be used to lay down the effects of different cell migration factors.