研究成果


第 1 到 76 筆結果，共 76 筆。

公開日期標題作者來源出版物scopusWOS全文
12022Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cellsCostanzo, Federico; Martínez Diez, Marta; Santamaría Nuñez, Gema; Díaz-Hernandéz, Juan Ignacio; Genes Robles, Carlos Mario; Díez Pérez, Javier; Compe, Emmanuel; Ricci, Romeo; TSAI-KUN LI ; Coin, Frédéric; Martínez Leal, Juan Fernando; Garrido-Martin, Eva Maria; Egly, Jean MarcEMBO molecular medicine13
22022Activation of multiple proteolysis systems contributes to acute cadmium cytotoxicityYeh Y.-H.; Tsai C.-C.; Chen T.-W.; Lee C.-H.; Chang W.-J.; Hsieh M.-Y.; TSAI-KUN LI Molecular and Cellular Biochemistry33
32020Retraction notice to "Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases" [Eur. J. Med. Chem. 190 (2020) 112074]Lee, Jiann-Fong; Chang, Ting-Yu; Liu, Zheng-Fang; Lee, Nian-Zhe; Yeh, Yen-Hsiu; Chen, Yi-Song; Chen, Tsung-Chih; Chou, Hao-Syun; TSAI-KUN LI ; Lee, Sung-Bau; Lin, Mei-HsiangEuropean journal of medicinal chemistry00
42020The role of extracellular vesicles in prostate cancer with clinical applicationsTai, Y.-L.; Lin, C.-J.; TSAI-KUN LI ; Shen, T.-L.; Hsieh, J.-T.; TANG-LONG SHEN Endocrine-Related Cancer1211
52020Selected ellipticine derivatives, known to target topoisomerase II, suppress the alternative lengthening of telomere (ALT) pathway in telomerase–negative cellsZencir S.; Hsieh M.-H.; Hsu J.-S.; Ergun Y.; Chou G.-L.; TSAI-KUN LI ; Teng S.-C.; Topcu Z.Journal of Cancer Research and Clinical Oncology33
62020Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerasesLee, Jiann-Fong; Chang, Ting-Yu; Liu, Zheng-Fang; Lee, Nian-Zhe; Yeh, Yen-Hsiu; Chen, Yi-Song; Chen, Tsung-Chih; Chou, Hao-Syun; TSAI-KUN LI ; Lee, Sung-Bau; Lin, Mei-HsiangEuropean Journal of Medicinal Chemistry109
72019The paracrine induction of prostate cancer progression by caveolin-1Lin, C.-J.; Yun, E.-J.; Lo, U.-G.; Tai, Y.-L.; Deng, S.; Hernandez, E.; Dang, A.; Chen, Y.-A.; Saha, D.; Mu, P.; Lin, H.; TSAI-KUN LI ; Shen, T.-L.; Lai, C.-H.; TANG-LONG SHEN Cell Death and Disease3937
82018Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathwayYeh Y.-H.; Hsiao H.-F.; Yeh Y.-C.; Chen T.-W.; TSAI-KUN LI Journal of Experimental and Clinical Cancer Research5350
92018Regioselective synthesis and biological evaluation of: N -substituted 2-aminoquinazolin-4-onesLiao Z.-Y.; Yeh W.-H.; Liao P.-Y.; Liu Y.-T.; Chen Y.-C.; Chen Y.-H.; Hsieh T.-H.; Lin C.-C.; Lu M.-H.; Chen Y.-S.; Hsu M.-C.; TSAI-KUN LI ; Chien T.-C.Organic and Biomolecular Chemistry1313
102017MicroRNA-183 Mediates Protective Postconditioning of the Liver by Repressing Apaf-1Lin H.-C.; Liu S.-Y.; Yen E.-Y.; TSAI-KUN LI ; I-RUE LAI Antioxidants and Redox Signaling1110
112017Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenograftsChien, M.-H.; Lee T.-H.; Lee W.-J.; Yeh Y.-H.; TSAI-KUN LI ; Wang P.-C.; Chen J.-J.; Chow J.-M.; Lin Y.-W.; Hsiao M.; Wang S.-W.; TZONG-HUEI LEE et al. Cancer Letters1412
122017Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistryWang Y.-R.; Chen S.-F.; Wu C.-C.; Liao Y.-W.; Lin T.-S.; Liu K.-T.; Chen Y.-S.; TSAI-KUN LI ; Chien T.-C.; NEI-LI CHAN Nucleic Acids Research6060
132016Rhapontigenin inhibits TGF-β-mediated epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradationYeh Y.-H.; Wang S.-W.; Yeh Y.-C.; Hsiao H.-F.; TSAI-KUN LI Oncology Reports1820
142015Involvement of p38 MAPK in the anticancer activity of cultivated cordyceps militarisChou S.-M.; Lai W.-J.; Hong T.; Tsai S.-H.; Chen Y.-H.; Kao C.-H.; Chu R.; Shen T.-L.; TSAI-KUN LI American Journal of Chinese Medicine86
152015Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancersHsieh M.-H.; Tsai C.-H.; Hung J.-J.; TSAI-KUN LI ; SHU-CHUN TENG ; Chang L.-T.; LING-WEI HSIN ; Teng S.-C.Cellular and Molecular Life Sciences89
162015Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological PotentialWang Y.-W.; Hong T.-W.; Tai Y.-L.; Wang Y.-J.; Tsai S.-H.; Lien P.T.K.; Chou T.-H.; Lai J.-Y.; Chu R.; Ding S.-T.; Irie K.; TSAI-KUN LI ; Tzean S.-S.; Shen T.-L.Evidence-based Complementary and Alternative Medicine116
172014Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cellsChou S.-M.; Lai W.-J.; Hong T.-W.; Lai J.-Y.; Tsai S.-H.; Chen Y.-H.; Yu S.-H.; Kao C.-H.; Chu R.; Ding S.-T.; TSAI-KUN LI ; Shen T.-L.Phytomedicine3627
182014DNA topoisomerase III alpha regulates P53-mediated tumor suppressionHsieh, Mei-Yi; Fan, Jia-Rong; Chang, Han-Wen; Chen, Hsiang-Chin; TANG-LONG SHEN ; SHU-CHUN TENG ; Yeh, Yen-Hsiu; TSAI-KUN LI Clinical Cancer Research108
192014A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase iYu C.-C.; Pan S.-L.; Chao S.-W.; SHIH-PING LIU ; Hsu J.-L.; Yang Y.-C.; TSAI-KUN LI ; Huang W.-J.; JIH-HWA GUH Biochemical Pharmacology2928
202013A negative feedback of the HIF-1α pathway via interferon-stimulated gene 15 and ISGylationYeh Y.-H.; Yang Y.-C.; Hsieh M.-Y.; Yeh Y.-C.; TSAI-KUN LI Clinical Cancer Research3025
212013Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesisYang Y.-C.; HAN-YI E. CHOU ; Shen T.-L.; Chang W.-J.; Tai P.-H.; TSAI-KUN LI Antioxidants and Redox Signaling1918
222013DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lambliaLin B.-C.; Su L.-H.; Weng S.-C.; Pan Y.-J.; NEI-LI CHAN ; TSAI-KUN LI ; Wang H.-C.; CHIN-HUNG SUN PLoS Neglected Tropical Diseases119
232013On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsWu C.-C.; Li Y.-C.; Wang Y.-R.; TSAI-KUN LI ; NEI-LI CHAN Nucleic Acids Research137134
242012QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cellsChen M.-C.; Pan S.-L.; Shi Q.; Xiao Z.; Lee K.-H.; TSAI-KUN LI ; Teng C.-M.Cancer Science1513
252012Cell type-specific effects of Adenosine 5′-triphosphate and pyrophosphate on the antitumor activity of doxorubicinWang J.-S.; Chang Y.-L.; Yu Y.-H.; Chen C.-Y.; Kao M.-C.; TSAI-KUN LI ; WAN-WAN LIN Cancer Science55
262012Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profilesLee C.-H.; Hsieh M.-Y.; LING-WEI HSIN ; Chen H.-C.; Lo S.-C.; Fan J.-R.; Chen W.-R.; Chen H.-W.; NEI-LI CHAN ; TSAI-KUN LI Biochemical Pharmacology1212
272012Docosahexaenoic acid suppresses the expression of FoxO and its target genesChen Y.-J.; Chen C.-C.; TSAI-KUN LI ; Wang P.-H.; Liu L.-R.; Chang F.-Y.; Wang Y.-C.; Yu Y.-H.; Lin S.-P.; Mersmann H.J.; PEI-HWA WANG Journal of Nutritional Biochemistry4139
282012Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencingWang L.-Y.; Lin S.-S.; Hung T.-H.; TSAI-KUN LI ; Lin N.-C.; NAI-CHUN LIN ; SHIH-SHUN LIN Molecular Plant-Microbe Interactions4845
292012Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathwayHsu J.-L.; Ho Y.-F.; TSAI-KUN LI ; Chen C.-S.; LIH-CHING HSU ; JIH-HWA GUH Biochemical Pharmacology1816
302011Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2Chou S.-M.; Huang T.-H.; Chen H.-C.; TSAI-KUN LI Cellular and Molecular Life Sciences98
312011Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathwayToh Y.-M.; TSAI-KUN LI Clinical Cancer Research2727
322011Structural basis of type II topoisomerase inhibition by the anticancer drug etoposideWu C.-C.; TSAI-KUN LI ; Farh L.; Lin L.-Y.; Lin T.-S.; Yu Y.-J.; Yen T.-J.; Chiang C.-W.; NEI-LI CHAN Science388380
332010EGF-induced Grb7 recruits and promotes ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cellsChu P.-Y.; TSAI-KUN LI ; Ding S.-T.; I-RUE LAI ; Shen T.-L.Journal of Biological Chemistry3938
342010Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responsesFan J.-R.; Huang T.-H.; Wen C.-Y.; Shen T.-L.; TSAI-KUN LI European Journal of Pharmacology44
352010Cellular processing determinants for the activation of damage signals in response to topoisomerase I-linked DNA breakageHuang T.-H.; Chen H.-C.; Chou S.-M.; Yang Y.-C.; Fan J.-R.; TSAI-KUN LI Cell Research1312
362009Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanismTai C.C.; Chen C.Y.; Lee, Hsuan-Shu ; Wang Y.C.; TSAI-KUN LI ; Mersamm H.J.; Ding S.T.; PEI-HWA WANG Journal of Biological Chemistry2222
372009Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modificationYou Q.-D.; Li Z.-Y.; Huang C.-H.; Yang Q.; Wang X.-J.; Guo Q.-L.; Chen X.-G.; He X.-G.; TSAI-KUN LI ; Chern J.-W.Journal of Medicinal Chemistry9171
382008Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugatesLING-WEI HSIN ; Wang H.-P.; Kao P.-H.; Lee O.; Chen W.-R.; Chen H.-W.; JIH-HWA GUH ; Chan Y.-L.; His C.-P.; Yang M.-S.; TSAI-KUN LI ; Lee C.-H.Bioorganic and Medicinal Chemistry4541
392008WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancersHsiao C.-J.; TSAI-KUN LI ; Chan Y.-L.; LING-WEI HSIN ; Liao C.-H.; Lee C.-H.; Lyu P.-C.; JIH-HWA GUH Biochemical Pharmacology3532
402008Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responsesFan J.-R.; Peng A.-L.; Chen H.-C.; Lo S.-C.; Huang T.-H.; TSAI-KUN LI DNA Repair4743
412007Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insultYeh T.-C.; Chiang P.-C.; TSAI-KUN LI ; Hsu J.-L.; CHUN-JUNG LIN ; Wang S.-W.; Peng C.-Y.; JIH-HWA GUH Biochemical Pharmacology123110
422007Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replicationLu C.-C.; Huang H.-T.; Wang J.-T.; Slupphaug G.; TSAI-KUN LI ; Wu M.-C.; Chen Y.-C.; Lee C.-P.; MEI-RU CHEN Journal of Virology3029
432007Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycleLin S.-C.; SHIH-CHIEH CHUEH ; Hsiao C.-J.; TSAI-KUN LI ; Chen T.-H.; Liao C.-H.; Lyu P.-C.; JIH-HWA GUH Neoplasia6158
442006Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cellsChiang P.-C.; FAN-LU KUNG ; Huang D.-M.; TSAI-KUN LI ; Fan J.-R.; Pan S.-L.; Shen Y.-C.; JIH-HWA GUH European Journal of Pharmacology2324
452006Involvement of topoisomerase III in telomere-telomere recombinationSHU-CHUN TENG ; Huang W.-H.; TSAI-KUN LI ; Tsai Y.-L.; Wu K.-J.; Tseng S.-F.; Teng S.-C.Journal of Biological Chemistry4341
462006Distribution of gyrase and topoisomerase IV on bacterial nucleoid: Implications for nucleoid organizationHsu Y.-H.; Chung M.-W.; TSAI-KUN LI Nucleic Acids Research3028
472004Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell DeathDaroui P.; Desai S.D.; TSAI-KUN LI ; Liu A.A.; Liu L.F.Journal of Biological Chemistry118112
482004Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Influence on topoisomerase I-targeting activity and cytotoxicityRuchelman A.L.; Kerrigan J.E.; TSAI-KUN LI ; Zhou N.; Liu A.; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry3131
492004Drug targeting of HIV-1 RNA·DNA hybrid structures: Thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replicationTSAI-KUN LI ; Barbieri C.M.; Lin H.-C.; Rabson A.B.; Yang G.; Fan Y.; Gaffney B.L.; Jones R.A.; Pilch D.S.Biochemistry1918
502003Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agentsMakhey D.; Li D.; Zhao B.; Sim S.-P.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry4545
5120038,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicityLi D.; Zhao B.; Sim S.-P.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry4041
522003Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agentsSingh S.K.; Ruchelman A.L.; Zhou N.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Medicinal Chemistry Research8
5320035H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activityRuchelman A.L.; Singh S.K.; Ray A.; Wu X.H.; Yang J.-M.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry111109
542003Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeastQi H.; TSAI-KUN LI ; Kuo D.; Nur-E-Kamal A.; Liu L.F.Journal of Biological Chemistry5655
552003Aminoglycoside complexation with a DNA·RNA hybrid duplex: The thermodynamics of recognition and inhibition of RNA processing enzymesBarbieri C.M.; TSAI-KUN LI ; Guo S.; Wang G.; Shallop A.J.; Pan W.; Yang G.; Gaffney B.L.; Jones R.A.; Pilch D.S.Journal of the American Chemical Society3128
562003Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer DrugTSAI-KUN LI ; Houghton P.J.; Desai S.D.; Daroui P.; Liu A.A.; Hars E.S.; Ruchelman A.L.; LaVoie E.J.; Liu L.F.Cancer Research10197
572003Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-ones: Effect on topoisomerase-I targeting activity and cytotoxicitySingh S.K.; Ruchelman A.L.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Journal of Medicinal Chemistry5147
582003Acidic pH induces topoisomerase II-mediated DNA damageXiao H.; TSAI-KUN LI ; Yang J.-M.; Liu L.F.Proceedings of the National Academy of Sciences of the United States of America6854
592003Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signalsNur-E-Kamal A.; TSAI-KUN LI ; Zhang A.; Qi H.; Hars E.S.; Liu L.F.Journal of Biological Chemistry4743
602003Substituted dibenzo[c,h]cinnolines: Topoisomerase I-targeting anticancer agentsYu Y.; Singh S.K.; Liu A.; TSAI-KUN LI ; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry9592
612003DNA damage-mediated apoptosis induced by selenium compoundsZhou N.; Xiao H.; TSAI-KUN LI ; Nur-E-Kamal A.; Liu L.F.Journal of Biological Chemistry135128
6220022,3-Dimethoxybenzo[i]phenanthridines: Topoisomerase I-targeting anticancer agentsLi D.; Zhao B.; Sim S.-P.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry5051
632002Diaza- and triazachrysenes: Potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435Ruchelman A.L.; Singh S.K.; Wu X.; Ray A.; Yang J.-M.; TSAI-KUN LI ; Liu A.; Liu L.F.; LaVoie E.J.Bioorganic and Medicinal Chemistry Letters5656
642001Ubiquitin/26s proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cellsDesai S.D.; TSAI-KUN LI ; Rodriguez-Bauman A.; Liu L.F.; Rubin E.H.Cancer Research196191
652001Tumor cell death induced by topoisomerase-targeting drugsTSAI-KUN LI ; Liu L.F.Annual review of Pharmacology and Toxicology481450
662000The camptothecins: Unfolding their anticancer potential: IntroductionLiu L.F.; Desai S.D.; TSAI-KUN LI ; Yong M.A.O.; Sun M.E.I.; Sai-Peng S.I.M.Annals of the New York Academy of Sciences1
672000Mechanism of action of camptothecinLiu L.F.; Desai S.D.; TSAI-KUN LI ; Mao Y.; Sun M.; Sim S.-P.Annals of the New York Academy of Sciences449390
682000Human topoisomerase I poisoning by protoberberines: Potential roles for both drug-DNA and drug-enzyme interactionsTSAI-KUN LI ; Bathory E.; LaVoie E.J.; Srinivasan A.R.; Olson W.K.; Sauers R.R.; Liu L.F.; Pilch D.S.Biochemistry9784
692000Ubiquitin, SUMO-1, and UCRP in camptothesin sensitivity and resistanceDesai S.D.; Yong M.A.O.; Sun M.E.I.; TSAI-KUN LI ; Jiaxi W.U.; Liu L.F.; New JerseyAnnals of the New York Academy of Sciences2421
701999Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stressTSAI-KUN LI ; Chen A.Y.; Yu C.; Mao Y.; Wang H.; Liu L.F.Genes and Development150139
711998Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cellsSanders M.M.; Liu A.A.; TSAI-KUN LI ; Wu H.-Y.; Desai S.D.; Mao Y.; Rubin E.H.; LaVoie E.J.; Makhey D.; Liu L.F.Biochemical Pharmacology5552
721998DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazolesXu Z.; TSAI-KUN LI ; Kim J.S.; LaVoie E.J.; Breslauer K.J.; Liu L.F.; Pilch D.S.Biochemistry3939
731998Modulation of gyrase-mediated DNA cleavage and cell killing by ATPTSAI-KUN LI ; Liu L.F.Antimicrobial Agents and Chemotherapy1818
741997Incompatibility of Escherichia coli rho mutants with plasmids is mediated by plasmid-specific transcriptionTSAI-KUN LI ; Panchenko Y.A.; Drolet M.; Liu L.F.Journal of Bacteriology44
751997Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugarSim S.-P.; Gatto B.; Yu C.; Liu A.A.; TSAI-KUN LI ; Pilch D.S.; LaVoie E.J.; Liu L.F.Biochemistry3936
761996Cellular resistance to topoisomerase poisons.Rubin E.H.; TSAI-KUN LI ; Duann P.; Liu L.F.Cancer treatment and research370