Results 1-68 of 68 (Search time: 0.004 seconds).

Issue DateTitleAuthor(s)TypescopusWOSFulltext/Archive link
12018Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathwayYeh, Yen-Hsiu; Hsiao, Ho-Fu; Yeh, Yen-Cheng; Chen, Tien-Wen; TSAI-KUN LI journal article78
22018Regioselective synthesis and biological evaluation of N-substituted 2-aminoquinazolin-4-onesLiao, Zhen-Yuan; Yeh, Wen-Hsiung; Liao, Pen-Yuan; Liu, Yu-Ting; Chen, Ying-Cheng; Chen, Yi-Hung; Hsieh, Tsung-Han; Lin, Chia-Chi; Lu, Ming-Hsuan; Chen, Yi-Song; Hsu, Ming-Chih; TSAI-KUN LI ; Chien, Tun-Chengjournal article11
32017Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistryWang, Ying-Ren; Chen, Shin-Fu; Wu, Chyuan-Chuan; Liao, Yi-Wen; Lin, Te-Sheng; Liu, Ko-Ting; Chen, Yi-Song; TSAI-KUN LI ; Chien, Tun-Cheng; NEI-LI CHAN journal article139
42017microRNA-183 Mediates Protective Postconditioning of the Liver by Repressing Apaf-1Lin, Han-Chen; Liu, Shin-Yun; Yen, Er-Yen; TSAI-KUN LI ; I-RUE LAI journal article44
52017Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenograftsChien, Ming-Hsien; TZONG-HUEI LEE; Lee, Wei-Jiunn; Yeh, Yen-Hsiu; TSAI-KUN LI ; Wang, Po-Chuan; Chen, Jih-Jung; Chow, Jyh-Ming; Lin, Yung-Wei; Hsiao, Michael; Wang, Shih-Wei; KUO-TAI HUA journal article45
62016Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradationTSAI-KUN LI journal article1315
72015Involvement of p38 MAPK in the anticancer activity of cultivated cordyceps militarisTSAI-KUN LI ; TANG-LONG SHEN journal article33
82015Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancersSHU-CHUN TENG ; Hsieh, Meng-Hsun; TSAI-KUN LI ; Tsai, Cheng-Hui; Lin, Chuan-Chuan; Li, Tsai-Kun; Hung, Ting-Wei; Chang, Li-Te; Hsin, Ling-Wei; Teng, Shu-Chunjournal article33
92015Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological PotentialSHIH-TORNG DING ; TSAI-KUN LI ; TANG-LONG SHEN journal article72
102014Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells.SHIH-TORNG DING ; TSAI-KUN LI ; TANG-LONG SHEN journal article1716
112014DNA topoisomerase III alpha regulates P53-mediated tumor suppressionSHU-CHUN TENG ; TSAI-KUN LI ; TANG-LONG SHEN journal article33
122014A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase iYu, Chia-Chun; JIH-HWA GUH ; TSAI-KUN LI ; Pan, Shiow-Lin; Chao, Shi-Wei; SHIH-PING LIU ; Liu, Shih-Ping ; Hsu, Jui-Ling; Yang, Yu-Chen; Li, Tsia-Kun; Huang, Wei-Jan; Guh, Jih-Hwa journal article1615
132013On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsTSAI-KUN LI ; NEI-LI CHAN journal article6966
142013Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesisTSAI-KUN LI ; TANG-LONG SHEN journal article1514
152013DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lambliaNEI-LI CHAN ; TSAI-KUN LI ; CHIN-HUNG SUN journal article75
162013A negative feedback of the HIF-1α pathway via interferon-stimulated gene 15 and ISGylationTSAI-KUN LI journal article1212
172012Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencingWang, Li-Ya; NAI-CHUN LIN ; Lin, Shih-Shun ; SHIH-SHUN LIN ; TSAI-KUN LI ; Hung, Ting-Hsuan ; TANG-LONG SHEN ; Li, Tsai-Kun ; Lin, Nai-Chun ; TING-HSUAN HUNG ; Shen, Tang-Long journal article2827
182012Ischemic postconditioning protects liver from ischemia-reperfusion injury by modulating mitochondrial permeability transitionTSAI-KUN LI ; I-RUE LAI journal article2424
192012Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathwayJIH-HWA GUH ; TSAI-KUN LI ; LIH-CHING HSU ; YUNN-FANG HO journal article1613
202012Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profilesLING-WEI HSIN ; TSAI-KUN LI ; NEI-LI CHAN journal article1010
212012Docosahexaenoic acid suppresses the expression of FoxO and its target genesYU-JEN CHEN; SHIH-TORNG DING ; TSAI-KUN LI ; Chen, Chih-Chien; Li, Tsai-Kun ; Wnag, Pei-Hwa; Liu.Li-Ru; Chang, Fan-Ying; Wang, Ya-Ching; Yu, Yu-Hsiang; Lin, Shau-Ping ; Mersmann, Harry J; Ding, Shih-Torng journal article2827
222011Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathwayTSAI-KUN LI journal article1615
232011Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2TSAI-KUN LI journal article65
242011Structural basis of type II topoisomerase inhibition by the anticancer drug etoposideNEI-LI CHAN ; TSAI-KUN LI journal article235231
252010Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.TSAI-KUN LI ; TANG-LONG SHEN journal article44
262010Cellular processing determinants for the activation of damage signals in response to topoisomerase I-linked DNA breakageTSAI-KUN LI journal article87
272010EGF-induced Grb7 recruits and promotes ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells黃昱璋; SHIH-TORNG DING ; Chu, Pei-Yu; TSAI-KUN LI ; 蘇立欣; Li, Tsai-Kun ; Ding, Shih-Torng ; TANG-LONG SHEN ; 李爾博; Lai, I-Rue ; I-RUE LAI ; 邱培維; Shen, Tang-Long ; 孫錦虹 ; HUANG, YU-CHANG; SU, LI-HSIN; LEE, GILBERT A.; CHIU, PEI-WEI; SUN, CHIN-HUNG journal article2728
282009Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modificationTSAI-KUN LI journal article7357
292009Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanismHSUAN-SHU LEE ; Tai, Chen C.; Chen, Ching Y.; SHIH-TORNG DING ; CHING-YI CHEN ; Lee, Hsuan S.; TSAI-KUN LI ; Wang, Ya C.; Li, Tsai K.; Mersamm, Harry J.; Ding, Shih T.; Wang, Pei H.journal article1717
302008Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugatesLING-WEI HSIN ; JIH-HWA GUH ; TSAI-KUN LI journal article4136
312008Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responsesTSAI-KUN LI journal article3232
322008WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancersLING-WEI HSIN ; JIH-HWA GUH ; TSAI-KUN LI journal article3330
332007Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replicationMEI-RU CHEN ; TSAI-KUN LI journal article2021
342007Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insultJIH-HWA GUH ; CHUN-JUNG LIN ; TSAI-KUN LI journal article10494
352007Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycleJIH-HWA GUH ; TSAI-KUN LI journal article4645
362006Involvement of topoisomerase III in telomere-telomere recombinationSHU-CHUN TENG ; TSAI-KUN LI journal article3535
372006Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cellsJIH-HWA GUH ; FAN-LU KUNG ; TSAI-KUN LI journal article2121
382006Distribution of gyrase and topoisomerase IV on bacterial nucleoid: Implications for nucleoid organizationTSAI-KUN LI journal article2221
392004Defining the Molecular Interactions that are Important for the Poisoning of Human Topoisomerase I by Benzimidazoles and TerbenzimidazolesTSAI-KUN LI book-chapter00
402004Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Influence on topoisomerase I-targeting activity and cytotoxicityTSAI-KUN LI journal article2524
412004Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell DeathTSAI-KUN LI journal article9893
422004Drug targeting of HIV-1 RNA·DNA hybrid structures: Thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replicationTSAI-KUN LI journal article1514
432003Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeastTSAI-KUN LI journal article5453
442003DNA damage-mediated apoptosis induced by selenium compoundsTSAI-KUN LI journal article120115
452003Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signalsTSAI-KUN LI journal article4127
462003Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-ones: Effect on topoisomerase-I targeting activity and cytotoxicityTSAI-KUN LI journal article4340
4720038,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicityTSAI-KUN LI journal article3232
482003Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agentsTSAI-KUN LI journal article
492003Aminoglycoside complexation with a DNA·RNA hybrid duplex: The thermodynamics of recognition and inhibition of RNA processing enzymesTSAI-KUN LI journal article2725
502003Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agentsTSAI-KUN LI journal article4037
512003Acidic pH induces topoisomerase II-mediated DNA damageTSAI-KUN LI journal article4738
522003Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer DrugTSAI-KUN LI journal article
5320035H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activityTSAI-KUN LI journal article8889
542003Substituted dibenzo[c,h]cinnolines: Topoisomerase I-targeting anticancer agentsTSAI-KUN LI journal article7166
5520022,3-Dimethoxybenzo[i]phenanthridines: Topoisomerase I-targeting anticancer agentsTSAI-KUN LI journal article4743
562002Diaza- and triazachrysenes: Potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435TSAI-KUN LI journal article4848
572001Ubiquitin/26s proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cellsTSAI-KUN LI journal article
582001Tumor cell death induced by topoisomerase-targeting drugsTSAI-KUN LI book431394
592000Mechanism of action of camptothecinTSAI-KUN LI book
602000Human topoisomerase I poisoning by protoberberines: Potential roles for both drug-DNA and drug-enzyme interactionsTSAI-KUN LI journal article9080
612000Ubiquitin, SUMO-1, and UCRP in camptothesin sensitivity and resistanceTSAI-KUN LI book
621999Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stressTSAI-KUN LI journal article
631998Modulation of gyrase-mediated DNA cleavage and cell killing by ATPTSAI-KUN LI journal article
641998DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazolesTSAI-KUN LI journal article3838
651998Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cellsTSAI-KUN LI journal article5148
661997Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugarTSAI-KUN LI journal article3736
671997Incompatibility of Escherichia coli rho mutants with plasmids is mediated by plasmid-specific transcriptionTSAI-KUN LI journal article
681996Cellular resistance to topoisomerase poisonsRubin, E H; TSAI-KUN LI ; Duann, P; Liu, L Fjournal article340