研究成果


第 1 到 46 筆結果，共 46 筆。

公開日期標題作者來源出版物scopusWOS全文
12023Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer CellsTsai, Feng-Lung; Huang, Han-Li; Lai, Mei-Jung; Liou, Jing-Ping; Pan, Shiow-Lin; CHIA-RON YANG International journal of molecular sciences
22023The study of a novel CDK8 inhibitor E966-0530-45418 that inhibits prostate cancer metastasis in vitro and in vivoHo, Tai-Yuan; Sung, Ting-Yi; Pan, Shiow-Lin; Huang, Wei-Jan; Hsu, Kai-Cheng; Hsu, Jui-Yi; Lin, Tony Eight; Hsu, Chia-Ming; CHIA-RON YANG Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie21
32023Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitorsHsu, Jui-Yi; Hsu, Kai-Cheng; Sun, Ching; Chou, Ching-Hsuan; Lin, Tony Eight; Sung, Tzu-Ying; Tseng, Hui-Ju; Yen, Shih-Chung; CHIA-RON YANG ; Huang, Wei-JanBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie31
42022Ibuprofen treatment ameliorates memory deficits in rats with collagen-induced arthritis by normalizing aberrant MAPK/NF-κB and glutamatergic pathwaysZhang, Nai-You; Wang, Ting-Hsuan; Chou, Ching-Hsuan; Wu, Kuo-Chen; CHIA-RON YANG ; FAN-LU KUNG ; CHUN-JUNG LIN European Journal of Pharmacology3
52022Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitorsLin T.E.; Sung L.-C.; Chao M.-W.; Li M.; Zheng J.-H.; Sung T.-Y.; Hsieh J.-H.; CHIA-RON YANG ; Lee H.-Y.; Cho E.-C.; Hsu K.-C.Journal of Enzyme Inhibition and Medicinal Chemistry33
62022Identification and analysis of a selective DYRK1A inhibitorLin T.E.; Chao M.-W.; HuangFu W.-C.; Tu H.-J.; Peng Z.-X.; Su C.-J.; Sung T.-Y.; Hsieh J.-H.; Lee C.-C.; CHIA-RON YANG ; Pan S.-L.; Hsu K.-C.Biomedicine and Pharmacotherapy63
72022O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemiaYen S.-C.; Wu Y.-W.; Huang C.-C.; Chao M.-W.; Tu H.-J.; Chen L.-C.; Lin T.E.; Sung T.-Y.; Tseng H.-J.; Chu J.-C.; Huang W.-J.; CHIA-RON YANG ; HuangFu W.-C.; Pan S.-L.; Hsu K.-C.Phytomedicine55
82022Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatmentLin T.E.; CHIA-RON YANG ; Chou C.-H.; Hsu J.-Y.; Chao M.-W.; Sung T.-Y.; Hsieh J.-H.; Huang W.-J.; Hsu K.-C.Biomedicine and Pharmacotherapy54
92021Neuroprotective studies of evodiamine in an okadaic acid-induced neurotoxicityChou C.-H.; CHIA-RON YANG International Journal of Molecular Sciences1815
102021A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivoWu Y.-W.; Chao M.-W.; Tu H.-J.; Chen L.-C.; Hsu K.-C.; Liou J.-P.; CHIA-RON YANG ; Yen S.-C.; HuangFu W.-C.; Pan S.-L.Oncogenesis1516
112021Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approachChao M.-W.; Lin T.E.; HuangFu W.-C.; Chang C.-D.; Tu H.-J.; Chen L.-C.; Yen S.-C.; Sung T.-Y.; Huang W.-J.; CHIA-RON YANG ; Pan S.-L.; Hsu K.-C.Journal of Enzyme Inhibition and Medicinal Chemistry98
122020Anti-Inflammatory and Tau Phosphorylation-Inhibitory Effects of EupatinChou C.-H.; Hsu K.-C.; Lin T.E.; CHIA-RON YANG Molecules (Basel, Switzerland)1513
1320204-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1Jagtap A.D.; Kondekar N.B.; Hung P.-Y.; Hsieh C.-E.; CHIA-RON YANG ; Chen G.S.; Chern J.-W.Bioorganic Chemistry77
142019MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cellsHuang F.-I.; Wu Y.-W.; Sung T.-Y.; Liou J.-P.; Lin M.-H.; Pan S.-L.; CHIA-RON YANG Frontiers in Oncology1918
152019Moscatilin Ameliorates Tau Phosphorylation and Cognitive Deficits in Alzheimer's Disease ModelsHuang J.-M.; Huang F.-I.; CHIA-RON YANG Journal of Natural Products1818
162019Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivoHsieh Y.-L.; Tu H.-J.; Pan S.-L.; Liou J.-P.; CHIA-RON YANG Biochimica et Biophysica Acta - Molecular Cell Research3229
172018The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model articleFan S.-J.; Huang F.-I.; Liou J.-P.; CHIA-RON YANG Cell Death and Disease6664
182018The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cellsTu H.-J.; Lin Y.-J.; Chao M.-W.; Sung T.-Y.; Wu Y.-W.; Chen Y.-Y.; Lin M.-H.; Liou J.-P.; Pan S.-L.; CHIA-RON YANG Clinical Epigenetics2121
192018(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in VivoLee H.-Y.; Nepali K.; Huang F.-I.; Chang C.-Y.; Lai M.-J.; Li Y.-H.; Huang H.-L.; CHIA-RON YANG ; Liou J.-P.Journal of Medicinal Chemistry6260
2020185-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease PhenotypesLee H.-Y.; Fan S.-J.; Huang F.-I.; Chao H.-Y.; Hsu K.-C.; Lin T.E.; Yeh T.-K.; Lai M.-J.; Li Y.-H.; Huang H.-L.; CHIA-RON YANG ; Liou J.-P.Journal of Medicinal Chemistry5449
212017An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cellsChao M.-W.; Huang H.-L.; HuangFu W.-C.; Hsu K.-C.; Liu Y.-M.; Wu Y.-W.; Lin C.-F.; Chen Y.-L.; Lai M.-J.; Lee H.-Y.; Liou J.P.; Teng C.-M.; CHIA-RON YANG Oncotarget65
222017Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivoHuangfu W.-C.; Chao M.-W.; Cheng C.-C.; Wei Y.-C.; Wu Y.-W.; Liou J.-P.; Hsiao G.; Lee Y.-C.; CHIA-RON YANG Scientific Reports48
2320173-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activityLee H.-Y.; Lee J.-F.; Kumar S.; Wu Y.-W.; HuangFu W.-C.; Lai M.-J.; Li Y.-H.; Huang H.-L.; Kuo F.-C.; Hsiao C.-J.; Cheng C.-C.; CHIA-RON YANG ; Liou J.-P.European Journal of Medicinal Chemistry3837
2420162-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylaseLee H.-Y.; Chang C.-Y.; Su C.-J.; Huang H.-L.; Mehndiratta S.; Chao Y.-H.; Hsu C.-M.; Kumar S.; Sung T.-Y.; Huang Y.-Z.; Li Y.-H.; CHIA-RON YANG ; Liou J.-P.European Journal of Medicinal Chemistry2524
252016Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinomaChen M.-C.; Huang H.-H.; Lai C.-Y.; Lin Y.-J.; Liou J.-P.; Lai M.-J.; Li Y.-H.; Teng C.-M.; CHIA-RON YANG Oncotarget2020
262015Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesisHuang Y.-C.; Huang F.-I.; Mehndiratta S.; Lai S.-C.; Liou J.-P.; CHIA-RON YANG Oncotarget2324
272014Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytesCHIA-RON YANG ; Shih K.-S.; Liou J.-P.; Wu Y.-W.; Hsieh I.-N.; Lee H.-Y.; Lin T.-C.; JYH-HORNG WANG Journal of Molecular Medicine3827
282014Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activityMehndiratta S.; Hsieh Y.-L.; Liu Y.-M.; Wang A.W.; Lee H.-Y.; Liang L.-Y.; Kumar S.; Teng C.-M.; CHIA-RON YANG ; Liou J.-P.European Journal of Medicinal Chemistry4139
292014Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009Hsieh I.-N.; Liou J.-P.; Lee H.-Y.; Lai M.-J.; Li Y.-H.; CHIA-RON YANG Cell Death and Disease2929
3020131-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release SuppressorsLee H.-Y.; CHIA-RON YANG ; Lai M.-J.; Huang H.-L.; Hsieh Y.-L.; Liu Y.-M.; Yeh T.-K.; Li Y.-H.; Mehndiratta S.; Teng C.-M.; Liou J.-P.ChemBioChem1819
312013Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytesJYH-HORNG WANG ; Shih K.S.; Wu Y.W.; Wang A.W.; CHIA-RON YANG Osteoarthritis and Cartilage8879
322013Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)Lee H.-Y.; CHIA-RON YANG ; Lai M.-J.; Huang H.-L.; Hsieh Y.-L.; Liu Y.-M.; Yeh T.-K.; Li Y.-H.; Mehndiratta S.; Teng C.-M.; Liou J.-P.ChemBioChem00
332012Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytesShih K.-S.; JYH-HORNG WANG ; Wu Y.-W.; Teng C.-M.; Chen C.-C.; CHIA-RON YANG PLoS ONE87
342012Anti-Arthritic effects of magnolol in human interleukin 1β-Stimulated Fibroblast-Like synoviocytes and in a rat arthritis modelJYH-HORNG WANG ; Shih K.-S.; Liou J.-P.; Wu Y.-W.; Chang A.S.-Y.; Wang K.-L.; Tsai C.-L.; CHIA-RON YANG PLoS ONE2819
352011Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathwaysChen P.-H.; Peng C.-Y.; Pai H.-C.; Teng C.-M.; Chen C.-C.; CHIA-RON YANG Journal of Nutritional Biochemistry1713
362011Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathwaysHsieh I.-N.; Chang A.S.-Y.; Teng C.-M.; Chen C.-C.; CHIA-RON YANG Journal of Biomedical Science6965
372011Potent anti-inflammatory effects of denbinobin mediated by dual inhibition of expression of inducible no synthase and cyclooxygenase 2Liu H.-E.; Chang A.S.-Y.; Teng C.-M.; Chen C.-C.; Tsai A.-C.; CHIA-RON YANG Shock2427
382010Thiazolidinediones inhibit TNF-α-mediated osteoclast differentiation of RAW264.7 macrophages and mouse bone marrow cells through downregulation of NFATc1CHIA-RON YANG ; Lai C.-C.Shock2118
392009Combined treatment with denbinobin and fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma Bxpc-3 CellsCHIA-RON YANG ; JIH-HWA GUH ; Teng C.M.; Chen C.C.; Chen P.H.British Journal of Pharmacology1614
402009Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's diseaseCHIA-RON YANG ; Yu R.K.Journal of Neuroscience Research4438
412008Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-κB-dependent pathwayChen P.-H.; CHIA-RON YANG Journal of Immunology3434
422007Inhibition of neuronal migration by JONES antibody is independent of 9-O-acetyl GD3 in GD3-synthase knockout miceCHIA-RON YANG ; Liour S.S.; Dasgupta S.; Yu R.K.Journal of Neuroscience Research1110
432006High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-κB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathwayHo F.M.; WAN-WAN LIN ; Chen B.C.; Chao C.M.; CHIA-RON YANG ; LIAN-YU LIN ; Lai C.C.; SHING-HWA LIU ; Liau C.S.Cellular Signalling228213
442005Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-κB-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expressionCHIA-RON YANG ; Hsieh S.-L.; Ho F.-M.; WAN-WAN LIN Journal of Immunology8375
452004Decoy receptor 3 (Dcr3) induces osteoclast formation from monocyte/macrophage lineage precursor cellsCHIA-RON YANG ; JYH-HORNG WANG ; Hsieh S.L.; Wang S.M.; Hsu T.L.; WAN-WAN LIN Cell Death and Differentiation7672
462004Soluble Decoy Receptor 3 Induces Angiogenesis by Neutralization of TL1A, a Cytokine Belonging to Tumor Necrosis Factor Superfamily and Exhibiting Angiostatic ActionCHIA-RON YANG ; Hsieh S.-L.; Teng C.-M.; Ho F.-M.; Su W.-L.; WAN-WAN LIN Cancer Research10394