研究成果


第 1 到 61 筆結果，共 61 筆。

公開日期標題作者來源出版物scopusWOS全文
12024Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathwayHsu, Jui-Ling; Leu, Wohn-Jenn; LIH-CHING HSU ; Hsieh, Chia-Hsun; JIH-HWA GUH Oncology letters
22024Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanismDu, Chi-Min; Leu, Wohn-Jenn; Jiang, Yi-Huei; Chan, She-Hung; Chen, Ih-Sheng; Chang, Hsun-Shuo; LIH-CHING HSU ; Hsu, Jui-Ling; JIH-HWA GUH Naunyn-Schmiedeberg's archives of pharmacology
32024A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancerYe, Pei-Chen; Leu, Wohn-Jenn; Yeh, Tsung-Yu; Hsu, Yu-Tung; Lin, Yi-Chin; Wei, Zi-Yuan; Chen, Yi-Chin; Chiang, Yi-Chang; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; JI-WANG CHERN ; CHAO-WU YU ; JIH-HWA GUH The Prostate
42023Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancerChiang, Yi-Chang; Leu, Wohn-Jenn; Chen, Yi-Chin; Ye, Pei-Chen; Hsu, Yu-Tung; Hsiao, Yu-Chi; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; Huang, Hsu-Shan; JIH-HWA GUH The Prostate
52023Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal CancerChiu, Pei Fang; Chang, Chun Kai; Huang, Pin Shuo; Lin, You Yu; Lin, Chung Shun; Yang, Hui Yi; LIH-CHING HSU ; LINDA CHIA-HUI YU ; PI-HUI LIANG Journal of Medicinal Chemistry00
62023Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma CellsHsu, Ya-Fen; FAN-LU KUNG ; Huang, Tzu-En; Deng, Yi-Ning; JIH-HWA GUH ; Marchetti, Paolo; Marchesi, Elena; Perrone, Daniela; Navacchia, Maria Luisa; LIH-CHING HSU Molecules (Basel, Switzerland)33
72022Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based AssaysHung, Hsueh-Chih; Li, Li-Cheng; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU Molecules (Basel, Switzerland)31
82022The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling PathwaysWeng, Hao-Cheng; Sung, Chieh-Ju; Hsu, Jui-Ling; Leu, Wohn-Jenn; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU Frontiers in pharmacology96
92021Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitorsKao, Ting-Yu; Wu, Hwa-Wei; SHOEI-SHENG LEE ; PI-HUI LIANG ; JIH-HWA GUH ; LIH-CHING HSU Journal of food and drug analysis32
102021Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-FluorouracilChang, Chun-Kai; Chiu, Pei-Fang; Yang, Hui-Yi; Juang, Yu-Pu; Lai, Yen-Hsun; Lin, Tzung-Sheng; LIH-CHING HSU ; LINDA CHIA-HUI YU ; PI-HUI LIANG Journal of Medicinal Chemistry16
112020Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism StudiesLeu W.-J.; Chu J.-C.; Hsu J.-L.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Huang W.-J.; JIH-HWA GUH Molecules (Basel, Switzerland)88
122020Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma CellsHuang T.-E.; Deng Y.-N.; Hsu J.-L.; Leu W.-J.; Marchesi E.; Capobianco M.L.; Marchetti P.; Navacchia M.L.; JIH-HWA GUH ; Perrone D.; LIH-CHING HSU Frontiers in Pharmacology1918
132020Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest SignalingHsu J.-L.; Leu W.-J.; LIH-CHING HSU ; Ho C.-H.; SHIH-PING LIU ; JIH-HWA GUH Frontiers in Oncology119
142020Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancersChang Y.-C.; Tseng Y.-L.; Leu W.-J.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH International Journal of Molecular Sciences11
152020The (+)-brevipolide H displays anticancer activity against human castration-resistant prostate cancer: The role of oxidative stress and Akt/mTOR/p70S6K dependent pathways in G1 checkpoint arrest and apoptosisSheng Y.-H.; Leu W.-J.; Chen C.-N.; Hsu J.-L.; Liu Y.-T.; LIH-CHING HSU ; Hou D.-R.; JIH-HWA GUH Molecules44
162019Phosphodiesterase type 5 (PDE5) inhibitors sensitize topoisomerase II inhibitors in killing prostate cancer through PDE5-independent impairment of HR and NHEJ DNA repair systemsChang J.-F.; Hsu J.-L.; Sheng Y.-H.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Chan M.-L.; LIH-CHING HSU ; SHIH-PING LIU ; JIH-HWA GUH Frontiers in Oncology1113
172019The combination of MK-2206 and WZB117 exerts a synergistic cytotoxic effect against breast cancer cellsLi Y.-L.; Weng H.-C.; Hsu J.-L.; SHU-WHA LIN ; JIH-HWA GUH ; LIH-CHING HSU Frontiers in Pharmacology2422
182019Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer ActivityMarchesi E.; Chinaglia N.; Capobianco M.L.; Marchetti P.; Huang T.-E.; Weng H.-C.; JIH-HWA GUH ; LIH-CHING HSU ; Perrone D.; Navacchia M.L.ChemMedChem1717
192018Traversal of the Blood-Brain Barrier by Cleavable l -Lysine Conjugates of ApigeninWong T.-Y.; Tsai M.-S.; LIH-CHING HSU ; SHU-WHA LIN ; Liang P.-H.Journal of Agricultural and Food Chemistry66
202018Para-toluenesulfonamide induces anti-tumor activity through Akt-dependent and -independent mTOR/p70S6K pathway: Roles of lipid raft and cholesterol contentsHsu J.-L.; Leu W.-J.; LIH-CHING HSU ; SHIH-PING LIU ; Zhong N.-S.; JIH-HWA GUH Frontiers in Pharmacology1019
212017Using precursor ion scan of 184 with liquid chromatography-electrospray ionization-tandem mass spectrometry for concentration normalization in cellular lipidomic studiesChao, Hsi-Chun; GUAN-YUAN CHEN ; LIH-CHING HSU ; Liao, Hsiao-Wei; Yang, Sin-Yu; Wang, San-Yuan; Li, Yu-Liang; SUNG-CHUN TANG ; YUFENG JANE TSENG ; CHING-HUA KUO 2221
222017Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathwaysChan M.-L.; Yu C.-C.; Hsu J.-L.; Leu W.-J.; Chan S.-H.; LIH-CHING HSU ; SHIH-PING LIU ; Ivantcova P.M.; Dogan ?.; Br?se S.; Kudryavtsev K.V.; JIH-HWA GUH Oncotarget88
232016Gain-of-function p53 mutant with 21-bp deletion confers susceptibility to multidrug resistance in MCF-7 cellsTsou S.-H.; Hou M.-H.; LIH-CHING HSU ; Chen T.-M.; YEN-HUI CHEN International Journal of Molecular Medicine1412
242016Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: The role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathwaysLeu W.-J.; Swain S.P.; Chan S.-H.; Hsu J.-L.; SHIH-PING LIU ; Chan M.-L.; Yu C.-C.; LIH-CHING HSU ; Chou Y.-L.; Chang W.-L.; Hou D.-R.; JIH-HWA GUH Oncotarget1414
252016Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growthLai W.-T.; Cheng K.-L.; Baruchello R.; Rondanin R.; Marchetti P.; Simoni D.; Lee R.M.; JIH-HWA GUH ; LIH-CHING HSU Biochemical Pharmacology77
262016A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approachMarchetti P.; Pavan B.; Simoni D.; Baruchello R.; Rondanin R.; Mischiati C.; Feriotto G.; Ferraro L.; LIH-CHING HSU ; Lee R.M.; Dalpiaz A.European Journal of Pharmaceutical Sciences88
272016Downregulation of COMMD1 by MIR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cellsYeh D.-W.; Chen Y.-S.; Lai C.-Y.; Liu Y.-L.; Lu C.-H.; Lo J.-F.; Chen L.; LIH-CHING HSU ; Luo Y.; Xiang R.; Chuang T.-H.Cell Death and Differentiation3434
282015Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxinsWu, Kuo-Chen; Lu, Ya-Hsuan; Peng, Yi-Hsuan; LIH-CHING HSU ; CHUN-JUNG LIN Journal of Neurochemistry2315
292015Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insultChan M.-L.; Liang J.-W.; LIH-CHING HSU ; Chang W.-L.; SHOEI-SHENG LEE ; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology3933
302015Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - A crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activationChang W.-L.; LIH-CHING HSU ; Leu W.-J.; Chen C.-S.; JIH-HWA GUH Oncotarget3935
312015Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastomaHsu J.-L.; Liu F.-L.; LIH-CHING HSU ; Chang H.-S.; Leu W.-J.; Yu C.-C.; Chang W.-L.; Chen I.-S.; FAN-LU KUNG ; JIH-HWA GUH Oncotarget65
322015Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathwayHo C.-H.; Hsu J.-L.; SHIH-PING LIU ; LIH-CHING HSU ; Chang W.-L.; Chao C.C.-K.; JIH-HWA GUH Prostate1414
332014Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulationWang W.-T.; Chen Y.-H.; Hsu J.-L.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Ho Y.-F.; LIH-CHING HSU ; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology2725
342014The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA RepairChen B.Y.-H.; Huang C.-H.; Lin Y.-H.; Huang C.-C.; Deng C.-X.; LIH-CHING HSU Scientific Reports89
352014Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycleLeu W.-J.; Chang H.-S.; Chan S.-H.; Hsu J.-L.; Yu C.-C.; LIH-CHING HSU ; Chen I.-S.; JIH-HWA GUH PLoS ONE2624
362014A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathwayHsu J.-L.; SHIH-PING LIU ; Lee C.-C.; LIH-CHING HSU ; Ho Y.-F.; Huang H.-S.; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology1312
372014The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cellsLin Y.-H.; Chen B.Y.-H.; Lai W.-T.; Wu S.-F.; JIH-HWA GUH ; ANN-LII CHENG ; LIH-CHING HSU Naunyn-Schmiedeberg's Archives of Pharmacology3432
382013Synthesis and biological evaluation of novel C-aryl D-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitorsLin, Tzung-Sheng; Liw, Ya-Wen; Song, Jen-Shin; Hsieh, Tsung-Chih; Yeh, Hsien-Wei; LIH-CHING HSU ; CHUN-JUNG LIN ; Wu, Szu-Huei; PI-HUI LIANG Bioorganic and Medicinal Chemistry1311
392013Development of a novel non-radioactive cell-based method for the screening of SGLT1 and SGLT2 inhibitors using 1-NBDGChang, Hung-Chi; Yang, Su-Fu; Huang, Ching-Chun; Lin, Tzung-Sheng; PI-HUI LIANG ; CHUN-JUNG LIN ; LIH-CHING HSU Molecular BioSystems1716
402013Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascadesChan S.-H.; Leu W.-J.; LIH-CHING HSU ; Chang H.-S.; Hwang T.-L.; Chen I.-S.; Chen C.-S.; JIH-HWA GUH Biochemical Pharmacology1715
412013Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulationYu C.-C.; Wu P.-J.; Hsu J.-L.; Ho Y.-F.; LIH-CHING HSU ; Chang Y.-J.; Chang H.-S.; Chen I.-S.; JIH-HWA GUH Prostate2522
422012Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitorLIH-CHING HSU ; Durrant D.E.; Huang C.-C.; Chi N.-W.; Baruchello R.; Rondanin R.; Rullo C.; Marchetti P.; Grisolia G.; Simoni D.; Lee R.M.Investigational New Drugs1410
432012Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repairHsu J.-L.; Leong P.-K.; Ho Y.-F.; LIH-CHING HSU ; Lu P.-H.; Chen C.-S.; JIH-HWA GUH Cancer Letters2317
442012Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathwayHsu J.-L.; Ho Y.-F.; TSAI-KUN LI ; Chen C.-S.; LIH-CHING HSU ; JIH-HWA GUH Biochemical Pharmacology1816
452008A PP1-binding motif present in BRCA1 plays a role in its DNA repair functionYu Y.-M.; Pace S.M.; Allen S.R.; Deng C.-X.; LIH-CHING HSU International Journal of Biological Sciences2323
462007Identification and functional characterization of a PP1-binding site in BRCA1LIH-CHING HSU Biochemical and Biophysical Research Communications1616
472007Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: Implications for pathogenesis of ovarian cancerWilcox C.B.; Feddes G.O.; Willett-Brozick J.E.; LIH-CHING HSU ; DeLoia J.A.; Baysal B.E.BMC Cancer4140
482007Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinomaParikh R.A.; White J.S.; Huang X.; Schoppy D.W.; Baysal B.E.; Baskaran R.; Bakkenist C.J.; Saunders W.S.; LIH-CHING HSU ; Romkes M.; Gollin S.M.Genes Chromosomes and Cancer7265
492006Gene amplification and overexpression of protein phosphatase 1α in oral squamous cell carcinoma cell linesLIH-CHING HSU ; Huang X.; Seasholtz S.; Potter D.M.; Gollin S.M.Oncogene3937
502005Centrosome abnormalities in ovarian cancerLIH-CHING HSU ; Kapali M.; DeLoia J.A.; Gallion H.H.International Journal of Cancer4442
512004The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdRLIH-CHING HSU ; Lee R.M.; White R.L.Biochemical and Biophysical Research Communications44
522002Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1αLiu Y.; Virshup D.M.; White R.L.; LIH-CHING HSU Cancer Research3130
532001Identification of a γ-tubulin-binding domain in BRCA1LIH-CHING HSU ; Doan T.P.; White R.L.Cancer Research116109
541998Mapping of 55 new rat microsatellite markers from chromosome-specific librariesShepel L.A.; Lan H.; Brasic G.M.; Gheen M.E.; LIH-CHING HSU ; Haag J.D.; Gould M.N.Mammalian Genome168
551998BRCA1 is associated with the centrosome during mitosisLIH-CHING HSU ; White R.L.Proceedings of the National Academy of Sciences of the United States of America274271
561996Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesisHaag J.D.; LIH-CHING HSU ; Newton M.A.; Gould M.N.Molecular Carcinogenesis31
571994Genetic Identification of Mcs-1, a Rat Mammary Carcinoma Suppressor GeneLIH-CHING HSU ; Kennan W.S.; Shepel L.A.; Jacob H.J.; Szpirer C.; Szpirer J.; Lander E.S.; Gould M.N.Cancer Research6056
581994Bivariate flow karyotyping, sorting, and peak assignment of all rat chromosomesShepel L.A.; Morrissey L.W.; LIH-CHING HSU ; Gould M.N.Genomics2120
591993Cloning and Characterization of Overexpressed Genes in the Mammary Gland of Rat Strains Carrying the Mammary CarcinomaSuppressor (Mcs) GeneLIH-CHING HSU ; Gould M.N.Cancer Research1313
601991Molecular cloning of copenhagen rat krev-1 and rap1b cdnas and study of their association with mammary tumor resistance in the copenhagen ratLIH-CHING HSU ; Gould M.N.Carcinogenesis13
611990Molecular cloning of rat krev-1 cdna and analysis of the mrna levels in normal and nmu-induced mammary carcinomasHong H.J.; LIH-CHING HSU ; Gould M.N.Carcinogenesis69