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  1. NTU Scholars
National Taiwan University / College of Medicine / Brain and Mind Sciences

PEI-YU WANG

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Profile

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English Name/英文名
PEI-YU WANG
 
Full Name
王培育
 
Tel
+886-2-23123456 #88058
 
Email
wangpeiyu@ntu.edu.tw
 
Personal Site
Dr. Pei-Yu Wang Lab (王培育老師實驗室)
 
ORCID
IDhttps://orcid.org/0000-0002-1792-8935
 
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Education

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Current Position

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Experience

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Research Field

1. Calorie restriction and the aging brain--Understanding aging is a major challenge of our time, given demographic trends and the predicted burdens of an elder society. Studies investigating age-related diseases such as neurodegenerative diseases have already yielded significant insights into human senescence. Calorie restriction (CR) has emerged as the most effective intervention prolonging healthy lifespan across species, from yeast to flies to mammals. Although understanding of the role of CR in brain functions is still in its infancy, recent studies have provided some enlightenment. In a number of epidemiological studies, CR has been shown to decrease the risk for both Parkinson’s and Alzheimer’s disease. In animal models, CR is able to reduce the cognitive decline associated with Alzheimer’s disease and improve toxin-induced motor and memory dysfunctions. These observations highlight the potential for using CR-related molecules/pathways as targets for treating age-related disease. In my lab, we undertake a systematic study of the action of CR on the aging brain. Understanding the molecular basis of the effects of CR on cognition will help us to protect neurons from insults and promote mental fitness.
2. Development of anti-aging interventions--We have previously used high throughput gene expression profiling to explore the underlying mechanism of CR-induced lifespan extension. Several novel longevity genes were identified and they were potential targets for developing CR mimetics. In addition to the genetic approach, we also screened natural products (Chinese herbs) for their ability to delay the aging process and to treat neurodegenerative disease. The anti-aging effects were evaluated in mutant mice and flies having Alzheimer’s disease-, Parkinson’s disease- and Huntington’s disease-like phenotypes. These newly developed interventions are likely to benefit people with not only a longer lifespan, but also a healthier lifespan.
 
 

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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  • 方案一:臺灣大學計算機中心帳號登入
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