| 公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 |
1 | 2020 | Improved antithrombotic activity and diminished bleeding side effect of a PEGylated alphaIIb beta 3 antagonist, disintegrin | Kuo Y.-J.; Chang Y.T.; Chung C.-H.; Chuang W.-J.; TUR-FU HUANG | Toxins | 9 | 8 | |
2 | 2019 | A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti-angiogenesis effects by targeting VEGFR-2 signalling | Lien J.-C.; Chung C.-L.; TUR-FU HUANG ; Chang T.-C.; Chen K.-C.; Gao G.-Y.; Hsu M.-J.; Huang S.-W. | British Journal of Pharmacology | 14 | 13 | |
3 | 2019 | From discovery of snake venom disintegrins to a safer therapeutic antithrombotic agent | Kuo Y.-J.; Chung C.-H.; TUR-FU HUANG | Toxins | 21 | 18 | |
4 | 2019 | A novel alpha iIb beta 3 antagonist from snake venom prevents thrombosis without causing bleeding | Kuo Y.-J.; Chung C.-H.; Pan T.-Y.; Chuang W.-J.; TUR-FU HUANG | Toxins | 9 | 6 | |
5 | 2019 | Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 | Sung P.-S.; TUR-FU HUANG ; Hsieh S.-L. | Nature Communications | 141 | 134 | |
6 | 2018 | Inhibitory Effects of an Orally Active Thromboxane A2 Receptor Antagonist, nstpbp5185, on Atherosclerosis in ApoE-Deficient Mice | Huang S.-W.; Lien J.-C.; Kuo S.-C.; TUR-FU HUANG | Thrombosis and Haemostasis | 7 | 6 | |
7 | 2017 | Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet | Chang C.-H.; Chung C.-H.; Tu Y.-S.; Tsai C.-C.; Hsu C.-C.; Peng H.-C.; Tseng Y.J.; TUR-FU HUANG | Arteriosclerosis, Thrombosis, and Vascular Biology | 18 | 20 | |
8 | 2017 | Trimucrin, an Arg-Gly-Asp containing disintegrin, attenuates myocardial ischemia-reperfusion injury in murine by inhibiting platelet function | Hung Y.-C.; Kuo Y.-J.; Huang S.-S.; TUR-FU HUANG | European Journal of Pharmacology | 12 | 10 | |
9 | 2017 | ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation | Lu D.-H.; Hsu C.-C.; Huang S.-W.; Tu H.-J.; TUR-FU HUANG ; Liou H.-C.; Liao H.-M.; Chen C.-H.; WEN-MEI FU ; SUSAN SHUR-FEN GAU | Journal of Thrombosis and Haemostasis | 10 | 10 | |
10 | 2017 | Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1 | Chung C.H.; Chang C.H.; Hsu C.C.; Lin K.T.; Peng H.C.; TUR-FU HUANG | Scientific Reports | 12 | 10 | |
11 | 2017 | An alpha II b beta 3 antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia | Kuo Y.-J.; Chen Y.-R.; Hsu C.-C.; Peng H.-C.; TUR-FU HUANG | Journal of Thrombosis and Haemostasis | 10 | 9 | |
12 | 2016 | Improved antithrombotic activity and diminished bleeding side effect of a PEGylated alphaiIb beta 3 antagonist, disintegrin | Hsu C.-C.; Chuang W.-J.; Chung C.-H.; Chang C.-H.; Peng H.-C.; TUR-FU HUANG | Thrombosis Research | 6 | 6 | |
13 | 2016 | The disintegrin, trimucrin, suppresses LPS-induced activation of phagocytes primarily through blockade of NF-κB and MAPK activation | Hung Y.-C.; Hsu C.-C.; Chung C.-H.; TUR-FU HUANG | Naunyn-Schmiedeberg's Archives of Pharmacology | 16 | 13 | |
14 | 2016 | A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models | Huang S.-W.; Kuo H.-L.; Hsu M.-T.; YUFENG JANE TSENG ; SHU-WHA LIN ; Kuo S.-C.; Peng H.-C.; Lien J.-C.; TUR-FU HUANG | Thrombosis and Haemostasis | 11 | | |
15 | 2016 | Anti-thrombotic agents derived from snake venom proteins | TUR-FU HUANG ; Hsu C.-C.; Kuo Y.-J. | Thrombosis Journal | 20 | 0 | |
16 | 2016 | DDA suppresses angiogenesis and tumor growth of colorectal cancer in vivo through decreasing VEGFR2 signaling | Huang S.-W.; Lien J.-C.; Kuo S.-C.; TUR-FU HUANG | Oncotarget | 5 | 5 | |
17 | 2016 | Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade | Hsu C.-C.; Chuang W.-J.; Chung C.-H.; Chang C.-H.; Peng H.-C.; TUR-FU HUANG | Scientific Reports | 9 | 8 | |
18 | 2015 | 4-acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production | Chang C.-H.; TUR-FU HUANG ; Lin K.-T.; Hsu C.-C.; Chang W.-L.; Wang S.-W.; Ko F.-N.; Peng H.-C.; Chung C.-H. | Journal of Agricultural and Food Chemistry | 14 | 13 | |
19 | 2015 | Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis | Chang, Yao-Wen; Hsieh, Pei-Wen; Chang, Yu-Tsui; Lu, Meng-Hong; TUR-FU HUANG ; Chong, Kowit-Yu; Liao, Hsiang-Ruei; Cheng, Ju-Chien; YAO-WEN CHANG | Oncotarget | 74 | 62 | |
20 | 2014 | Inhibitory effects of polypeptides derived from a snake venom C-type lectin, aggretin, on tumor cell-induced platelet aggregation | Chang C.-H.; Chung C.-H.; Hsu C.-C.; Peng H.-C.; TUR-FU HUANG | Journal of Thrombosis and Haemostasis | 13 | 10 | |
21 | 2014 | PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling | Huang S.W.; Lien J.C.; Kuo S.C.; TUR-FU HUANG | British Journal of Pharmacology | 12 | 12 | |
22 | 2013 | Triflamp (Trimeresurus flavoviridis) | Tseng Y.-L.; TUR-FU HUANG | Handbook of Proteolytic Enzymes | 0 | 0 | |
23 | 2013 | Butein inhibits angiogenesis of human endothelial progenitor cells via the translation dependent signaling pathway | Chung C.-H.; Chang C.-H.; Chen S.-S.; Wang H.-H.; Yen J.-Y.; Hsiao C.-J.; Wu N.-L.; Chen Y.-L.; TUR-FU HUANG ; Wang P.-C.; Yeh H.-I.; Wang S.-W. | Evidence-based Complementary and Alternative Medicine | 35 | 25 | |
24 | 2013 | Yuwen02f1 suppresses LPS-induced endotoxemia and adjuvant-induced arthritis primarily through blockade of ROS formation, NFkB and MAPK activation | Hsu C.-C.; Lien J.-C.; Chang C.-W.; Chang C.-H.; Kuo S.-C.; TUR-FU HUANG | Biochemical Pharmacology | 78 | 75 | |
25 | 2013 | Kistomin | Hsu C.-C.; TUR-FU HUANG | Handbook of Proteolytic Enzymes | 0 | 0 | |
26 | 2012 | Antirestenosis effect of butein in the neointima formation progression | Chen Y.-N.; TUR-FU HUANG ; Chang C.-H.; Hsu C.-C.; Lin K.-T.; Wang S.-W.; Peng H.-C.; Chung C.-H. | Journal of Agricultural and Food Chemistry | 14 | 11 | |
27 | 2012 | Bp5250 inhibits vascular endothelial growth factor-induced angiogenesis and HIF-1alpha expression on endothelial cells | Lin K.-T.; Lien J.-C.; Chung C.-H.; Kuo S.-C.; TUR-FU HUANG | Naunyn-Schmiedeberg's Archives of Pharmacology | 5 | 6 | |
28 | 2012 | Antiangiogenic mechanisms of PJ-8, a novel inhibitor of vascular endothelial growth factor receptor signaling | Huang S.-W.; Lien J.-C.; Kuo S.-C.; TUR-FU HUANG | Carcinogenesis | 22 | 21 | |
29 | 2011 | Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin alphav beta 3-dependent pathway | Hsu C.-C.; Chuang W.-J.; Chang C.-H.; Tseng Y.-L.; Peng H.-C.; TUR-FU HUANG | Journal of Thrombosis and Haemostasis | 19 | 19 | |
30 | 2011 | The biologic activity of aggretin/rhodocytin, a snake venom C-type lectin protein (snaclec) | Chung C.-H.; TUR-FU HUANG | Toxins and Hemostasis: From Bench to Bedside | 1 | 0 | |
31 | 2011 | The discovery of disintegrins | TUR-FU HUANG | Toxins and Hemostasis: From Bench to Bedside | 2 | 0 | |
32 | 2011 | Biological activities of snake venom metalloproteinases on platelets, neutrophils, endothelial cells, and extracellular matrices | Hsu C.-C.; TUR-FU HUANG | Toxins and Hemostasis: From Bench to Bedside | 4 | 0 | |
33 | 2011 | NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A 2 synthesis and calcium entry | Kuo H.-L.; Lien J.-C.; Chang C.-H.; Chung C.-H.; Kuo S.-C.; Hsu C.-C.; Peng H.-C.; TUR-FU HUANG | British Journal of Pharmacology | 5 | 6 | |
34 | 2010 | A selective serotonin reuptake inhibitor, citalopram, inhibits collagen-induced platelet aggregation and activation | Tseng Y.-L.; Chiang M.-L.; TUR-FU HUANG ; Su K.-P.; Lane H.-Y.; Lai Y.-C. | Thrombosis Research | 56 | 52 | |
35 | 2010 | NP-184[2-(5-methyl-2-furyl) benzimidazole], a novel orally active antithrombotic agent with dual antiplatelet and anticoagulant activities | Kuo H.-L.; Lien J.-C.; Chung C.-H.; Chang C.-H.; SHYH-CHYI LO ; Tsai I.-C.; Peng H.-C.; Kuo S.-C.; TUR-FU HUANG | Naunyn-Schmiedeberg's Archives of Pharmacology | 29 | 23 | |
36 | 2010 | A novel compound, NP-184, inhibits the vascular endothelial growth factor induced angiogenesis | Lin K.-T.; Lien J.-C.; Chung C.-H.; Kuo S.-C.; TUR-FU HUANG | European Journal of Pharmacology | 22 | 20 | |
37 | 2010 | A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation | Chang C.-H.; Chung C.-H.; Hsu C.-C.; Huang T.-Y.; TUR-FU HUANG | Journal of Thrombosis and Haemostasis | 38 | 31 | |
38 | 2010 | Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells | Shieh J.-M.; TUR-FU HUANG ; Hung C.-F.; Chou K.-H.; Tsai Y.-J.; Wu W.-B. | British Journal of Pharmacology | 56 | 53 | |
39 | 2009 | 2′-Ethoxy-5′-methoxy-2-(5-methylthienyl)chalcone inhibits collagen-induced protein tyrosine phosphorylation and thromboxane formation during platelet aggregation and adhesion | Lo H.-M.; TUR-FU HUANG ; Lin C.-N.; Peng H.-C.; Wu W.-B. | Pharmacology | 3 | 2 | |
40 | 2009 | The integrin alpha 2 beta 1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production | Chung C.-H.; Lin K.-T.; Chang C.-H.; Peng H.-C.; TUR-FU HUANG | British Journal of Pharmacology | 40 | 36 | |
41 | 2008 | FcγRII mediates platelet aggregation caused by disintegrins and GPIIb/IIIa monoclonal antibody, AP2 | TUR-FU HUANG ; Chang C.-H.; Ho P.-L.; Chung C.-H. | Experimental Hematology | 8 | 8 | |
42 | 2008 | A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions | Hsu C.C.; Wu W.B.; TUR-FU HUANG | Journal of Thrombosis and Haemostasis | 40 | 32 | |
43 | 2008 | Synthesis of 2,3-disubstituted 1,4-naphthoquinones as antiplatelet agents | Lien J.-C.; Wu C.-R.; Hour M.-J.; Huang L.-J.; TUR-FU HUANG ; Kuo S.-C. | Archiv der Pharmazie | 3 | 3 | |
44 | 2008 | Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion | Hung C.-F.; TUR-FU HUANG ; Chen B.-H.; Shieh J.-M.; Wu P.-H.; Wu W.-B. | European Journal of Pharmacology | 112 | 95 | |
45 | 2008 | The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding | Chang C.-H.; Chung C.-H.; Kuo H.-L.; Hsu C.-C.; TUR-FU HUANG | Journal of Thrombosis and Haemostasis | 24 | 24 | |
46 | 2007 | Antithrombotic effect of a protein-type I class snake venom metalloproteinase, kistomin, is mediated by affecting glycoprotein Ib-von Willebrand factor interaction | Hsu C.-C.; Wu W.-B.; Chang Y.-H.; Kuo H.-L.; TUR-FU HUANG | Molecular Pharmacology | 26 | 24 | |
47 | 2007 | A segment of Staphylococcus aureus clumping factor A with fibrinogen-binding activity (ClfA221-550) inhibits platelet-plug formation in mice | Liu C.-Z.; TUR-FU HUANG ; Tsai P.-J.; Tsai P.-J.; Chang L.-Y.; Chang M.-C. | Thrombosis Research | 16 | 14 | |
48 | 2006 | Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts | Tang C.-H.; RONG-SEN YANG ; Huang T.-H.; Lu D.-Y.; Chuang W.-J.; TUR-FU HUANG ; WEN-MEI FU | Molecular Pharmacology | 136 | 124 | |
49 | 2006 | Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation | SHYH-CHYI LO ; Hung C.-Y.; Lin D.-T.; Peng H.-C.; TUR-FU HUANG | Journal of Biomedical Science | 47 | 39 | |
50 | 2005 | Primary structure and antiplatelet mechanism of a snake venom metalloproteinase, acurhagin, from Agkistrodon acutus venom | Wang W.-J.; Shih C.-H.; TUR-FU HUANG | Biochimie | 41 | 35 | |
51 | 2005 | Rhodostomin inhibits thrombin-enhanced adhesion of ROS 17/2.8 cells through the blockade of alphav beta 3 integrin | RONG-SEN YANG ; Chiang H.-S.; Tang C.-H.; Yeh C.-S.; TUR-FU HUANG | Toxicon | 10 | 10 | |
52 | 2005 | Inhibition of adipogenesis by RGD-dependent disintegrin | Lin Y.-T.; Tang C.-H.; Chuang W.-J.; Wang S.-M.; TUR-FU HUANG ; WEN-MEI FU | Biochemical Pharmacology | 21 | 17 | |
53 | 2005 | Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia | Chou H.-C.; Chen J.-J.; Duh C.-Y.; TUR-FU HUANG ; Chen I.-S. | Planta Medica | 24 | 19 | |
54 | 2005 | Inhibition of tumor formation by snake venom disintegrin | RONG-SEN YANG ; Tang C.-H.; Chuang W.-J.; Huang T.-H.; Peng H.-C.; TUR-FU HUANG ; WEN-MEI FU | Toxicon | 72 | 66 | |
55 | 2005 | (-)-Epigallocatechin-3-gallate, a polyphenolic compound from green tea, inhibits fibroblast adhesion and migration through multiple mechanisms | Hung C.-F.; TUR-FU HUANG ; Chiang H.-S.; Wu W.-B. | Journal of Cellular Biochemistry | 44 | 40 | |
56 | 2004 | Rhodostomin, a disintegrin, inhibits adhesion of neutrophils to fibrinogen and attenuates superoxide production | Tseng Y.-L.; Peng H.-C.; TUR-FU HUANG | Journal of Biomedical Science | 21 | 23 | |
57 | 2004 | Inhibitory effects of human alpha2-macroglobulin and mouse serum on the PSGL-1 and glycoprotein Ib proteolysis by a snake venom metalloproteinase, triflamp | Tseng Y.-L.; Wu W.-B.; Hsu C.-C.; Peng H.-C.; TUR-FU HUANG | Toxicon | 10 | 9 | |
58 | 2004 | Differential susceptibility of osteosarcoma cells and primary osteoblasts to cell detachment caused by snake venom metalloproteinase protein | Tang C.-H.; RONG-SEN YANG ; Liu C.-Z.; TUR-FU HUANG ; WEN-MEI FU | Toxicon | 10 | 12 | |
59 | 2004 | Inhibition of neuropathic pain by a potent disintegrin - Triflavin | WEN-MEI FU ; Chang T.-K.; WEI-ZEN SUN ; Ling Q.-D.; Peng H.-C.; Liou H.-C.; Lu D.-Y.; TUR-FU HUANG | Neuroscience Letters | 19 | 17 | |
60 | 2004 | Triflamp, a snake venom matalloproteinase, reduces neutrophil-platelet adhesion through proteolysis of PSGL-I but not glycoprotein lbalpha | Tseng Y.-L.; Lee C.-J.; Hsu C.-C.; TUR-FU HUANG | Thrombosis and Haemostasis | 10 | 9 | |
61 | 2004 | A novel P-I class metalloproteinase with broad substrate-cleaving activity, agkislysin, from Agkistrodon acutus venom | Wang W.-J.; Shih C.-H.; TUR-FU HUANG | Biochemical and Biophysical Research Communications | 90 | 86 | |
62 | 2004 | Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor | Chung C.-H.; Wu W.-B.; TUR-FU HUANG | Blood | 43 | 44 | |
63 | 2004 | Effects of a snake venom metalloproteinase, triflamp, on platelet aggregation, platelet-neutrophil and neutrophil-neutrophil interactions: Involvement of platelet GPlbalpha and neutrophil PSGL-I | Tseng Y.-L.; Lee C.-J.; TUR-FU HUANG | Thrombosis and Haemostasis | 20 | 18 | |
64 | 2003 | Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis | Wu W.-B.; TUR-FU HUANG | Experimental Cell Research | 65 | 59 | |
65 | 2003 | Disintegrin causes proteolysis of beta -catenin and apoptosis of endothelial cells: Involvement of cell - Cell and cell - ECM interactions in regulating cell viability | Wu W.-B.; Peng H.-C.; TUR-FU HUANG | Experimental Cell Research | 58 | 52 | |
66 | 2003 | A tetrameric glycoprotein Ib-binding protein, agglucetin, from Formosan pit viper: Structure and interaction with human platelets | Wang W.-J.; Ling Q.-D.; Liau M.-Y.; TUR-FU HUANG | Thrombosis and Haemostasis | 22 | 21 | |
67 | 2002 | Purification and characterization of a novel metalloproteinase, acurhagin, from Agkistrodon acutus venom | Wang W.-J.; TUR-FU HUANG | Thrombosis and Haemostasis | 63 | 54 | |
68 | 2002 | Differential regulation of fibronectin fibrillogenesis by protein kinases A and C | Lin W.; Wang S.-M.; TUR-FU HUANG ; WEN-MEI FU | Connective Tissue Research | 15 | 26 | |
69 | 2002 | Trimucytin, a collagen-like snake venom protein, activates platelets independent of I-domain within alpha2 subunit of alpha2 beta 1 integrin | Liu C.-Z.; Wu T.-F.; TUR-FU HUANG ; Wu D.-H.; Lin G.-L. | Thrombosis Research | 7 | 7 | |
70 | 2001 | Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonist | Yeh C.-H.; Chang M.-C.; Peng H.-C.; TUR-FU HUANG | British Journal of Pharmacology | 37 | 30 | |
71 | 2001 | Crotalin, a vWF and GP Ib cleaving metalloproteinase from venom of Crotalus atrox | Wu W.-B.; Peng H.-C.; TUR-FU HUANG | Thrombosis and Haemostasis | 35 | 30 | |
72 | 2001 | Aggretin, a C-type lectin protein, induces platelet aggregation via integrin alpha2 beta 1 and gpib in a phosphatidylinositol 3-kinase independent pathway | Chung C.-H.; Peng H.-C.; TUR-FU HUANG | Biochemical and Biophysical Research Communications | 34 | 34 | |
73 | 2001 | Modulation of protein kinase A activation by fibronectin matrix proteins at developing neuromuscular synapses in Xenopus laevis cell cultures | HORNG-HUEI LIOU ; WAN-WAN LIN ; Liou H.-C.; TUR-FU HUANG ; WEN-MEI FU | Molecular Pharmacology | 5 | 4 | |
74 | 2001 | Viper venom components affecting angiogenesis | TUR-FU HUANG ; Yeh C.H.; Wu W.B. | Haemostasis | 31 | 29 | |
75 | 2001 | Purification, molecular cloning and mechanism of action of graminelysin I, a snake-venom-derived metalloproteinase that induces apoptosis of human endothelial cells | Wu W.B.; SHAN-CHWEN CHANG ; Liau M.-Y.; TUR-FU HUANG | Biochemical Journal | 67 | 58 | |
76 | 2001 | Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alphav/ beta 3 blockade of endothelial cells | Yeh C.-H.; Peng H.-C.; RONG-SEN YANG ; TUR-FU HUANG | Molecular Pharmacology | 101 | 91 | |
77 | 2001 | A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist | Wang W.-J.; TUR-FU HUANG | Thrombosis and Haemostasis | 33 | 30 | |
78 | 2000 | Rhodostomin inhibits the transforming growth factor- beta 1-enhanced adhesion activity of ROS 17/2.8 osteosarcoma cells | RONG-SEN YANG ; TUR-FU HUANG | Tohoku Journal of Experimental Medicine | 3 | 1 | |
79 | 2000 | Agkistin, a snake venom-derived glycoprotein Ib antagonist, disrupts von Willebrand factor-endothelial cell interaction and inhibits angiogenesis | Yeh C.-H.; Wang W.-C.; Hsie T.-T.; TUR-FU HUANG | Journal of Biological Chemistry | 37 | 30 | |