Studies of Psychiatric Predisposing Factors, Treatment-Related Cardiovascular Effects, and Prognostic Factors Associated with Antimuscarinic Drug (Tolterodine) for Female Overactive Bladder Syndrome 1 = 女性膀胱過動症患者之精神方面致病因子，抗毒蕈鹼素藥物(Tolterodine)治療對心臟系統之影響，以及影響治療之預後因子的探討

Project title
女性膀胱過動症患者之精神方面致病因子，抗毒蕈鹼素藥物(Tolterodine)治療對心臟系統之影響，以及影響治療之預後因子的探討
Internal ID
NSC97-2314-B002-082
Principal Investigator
Start Date
August 1, 2008
End Date
July 12, 2009
Investigators
Organizations
Partner Organizations
Project Web Site
Keywords
overactive bladder syndrome
antimuscarinic drug
urodynamic studies
Description
Background/Purpose: The overactive bladder syndrome (OAB) affects around 17 % of female population. However, the etiology of OAB was complicated and unclear in many aspects. In particular, the research about psychiatric aspect of etiology in OAB was paucity. Besides, research about prognostic factors and impact of cardiovascular system of OAB treatment was also paucity. Therefore the aims of our study were (1) to analyze the etiology of OAB in psychiatric aspects; (2) to analyze the prognostic factors associated with tolterodine treatment; (3) to analyze the differences of cardiac conduction and heart rate variability before and after tolterodine treatment; (4) to analyze the differences of arterial stiffness between non-OAB and OAB female patients, and before and after tolterodine treatment. Patients and Methods: We will perform a prospective study to recruit 130 female OAB patients at the outpatient clinic of Department of Obstetrics and Gynecology of National Taiwan University Hospital. All OAB female patients will be asked to complete OAB-q, UDI-6&IIQ-7, brief symptom rating scale (BSRS), Maudsley personality inventory (MPI) and adaptability, partnership, growth, affection, and resolve (APGAR) questionnaires, standard 12-leads electrocardiography (ECG), 20 minutes Holter monitoring, cardio-ankle vascular index (CAVI) test, voiding diary, 20-min pad test and urodynamic studies before and after 12 weeks’ tolterodine treatment. Besides, we will also recruit 130 non-OAB female patients in our outpatient clinic, and they will be asked to complete the above questionnaires and examinations except pad test and urodynamic studies. The above parameters will be compared between non-OAB and OAB subjects, and also before and after treatment. STATA software was used for statistical analyses. Possible Results: With the comparison of the above parameters between non-OAB and OAB patients, and also before and after treatment, we can answer the questions that (1) the role of psychiatric aspects in OAB; (2) the psychiatric and urodynamic factors that affect outcome of tolterodine treatment; (3) the differences of cardiac conduction and heart rate variability before and after tolterodine treatment; (4) the differences of arterial stiffness between non-OAB and OAB female patients, and before and after tolterodine treatment.

臺大位居世界頂尖大學之列，為永久珍藏及向國際展現本校豐碩的研究成果及學術能量，圖書館整合機構典藏（NTUR）與學術庫（AH）不同功能平台，成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動，應用在學術研究上是透過將研究著作公開供使用者自由取閱，以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力，NTU Scholars即為本校的開放取用典藏（OA Archive）平台。（點選深入了解OA）

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