Project title
高膽固醇血症(hypercholesterolemia)會惡化根尖牙周炎病情:可能作用因子與治療方針的探討
Internal ID
NSTC113-2314-B002-065-MY2
Principal Investigator
Start Date
August 1, 2025
End Date
July 31, 2026
Organizations
Partner Organizations
Hypercholesterolemia Exacerbates Apical Periodontitis Propagation: Possible Pathogenesis and Potential Therapeutic Strategy (II)
Keywords
Hypercholesterolemia
apical periodontitis
pathogenesis
therapeutic strategy
Description
體內伴隨著肥胖/高膽固醇血症(hypercholesterolemia)而升高的27-hydroxycholesterol (27HC)可能會增加根尖牙周炎的發炎強度，造成傷口癒合能力下降，術後預後不佳等問題。Felodipine這種已長期被用來治療高血壓，安全且便宜的老藥對此窘境可能會有療效，我們將測試Felodipine可否能減低27HC對根尖牙周炎的影響，並深入探討Felodipine抑制27HC生成的作用原理。對於現今人口逐漸老化，肥胖人口比例升高，會使根尖牙周炎的病程發展更為複雜，我們的發現具有臨床醫療價值，值得深入探討。