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.National Taiwan University / 國立臺灣大學
Project / 研究計畫
Explore Underlying Matrix Protein-Related Molecular and Cellular Pathomechanisms in the Interplay between Renal and Cardiac Dysfunction = 探究基質蛋白於腎心功能障礙之潛在調控與細胞病理機制
Explore Underlying Matrix Protein-Related Molecular and Cellular Pathomechanisms in the Interplay between Renal and Cardiac Dysfunction = 探究基質蛋白於腎心功能障礙之潛在調控與細胞病理機制
Details
Primary Data
Project title
探究基質蛋白於腎心功能障礙之潛在調控與細胞病理機制
Internal ID
113-2314-B-002-288-MY3
Principal Investigator
CHI-TING SU
Start Date
August 1, 2025
End Date
July 31, 2026
Organizations
Medicine-NTUCC
Partner Organizations
National Science and Technology Council
Description
Keywords
Renal fibrosis
Cardiac fibrosis
LTBP4
LTBP
Matrix protein
Description
此計畫乃持續性地了解間質蛋白於組織纖維化的調控影響,著重於對腎纖維化及心纖維化的控制機轉,進而推向腎臟與心臟交互影響的可能病因;目前我們發現間質蛋白對新生血管及粒線體功能穩定性之影響,然更進一步的認識仍是需要的,甚或,對研發藥物介入,對醫療照護逐漸成為重擔的腎衰竭及心衰竭更或是腎心症的理論基礎,提供更具體仔細的建構,亦導向更好的新藥或新型療法,對疾病具有更好的控制及患者將有更優質的預後。
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